Prognostic Value and Optimal Sampling Time of S-100B Protein for Outcome Prediction in Cardiac Arrest Patients Treated with Therapeutic Hypothermia
DC Field | Value | Language |
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dc.contributor.author | 김형석 | - |
dc.contributor.author | 정호성 | - |
dc.contributor.author | 임용수 | - |
dc.contributor.author | 우재혁 | - |
dc.contributor.author | 장재호 | - |
dc.contributor.author | 장지용 | - |
dc.contributor.author | 양혁준 | - |
dc.date.available | 2020-02-28T19:45:15Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2586-6052 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13378 | - |
dc.description.abstract | Background: The aim of this study was to determine the prognostic value and optimal sampling time of serum S-100B protein for the prediction of poor neurological outcomes in post-cardiac arrest (CA) patients treated with therapeutic hypothermia (TH). Methods: We prospectively measured serum S100 calcium binding protein beta subunit (S-100B protein) levels 12 times (0-96 hours) after the return of spontaneous circulation (ROSC). The patients were classified into two groups based on cerebral performance category (CPC): the good neurological outcome group (CPC 1-2 at 6 months) and the poor neurological outcome group (CPC 3-5). We compared serial changes and serum S-100B protein levels at each time point between the two groups and performed receiver operating characteristic curve analysis for the prediction of poor neurological outcomes. Results: A total of 40 patients were enrolled in the study. S-100B protein levels peaked at ROSC (0 hour), decreased rapidly to 6 hours and maintained a similar level thereafter. Serum S-100B protein levels in the poor CPC group (n = 22) were significantly higher than in the good CPC group (n = 18) at all time points after ROSC except at 4 hours. The time points with highest area under curve were 24 (0.829) and 36 (0.837) hours. The cut-off value, the sensitivity (24/36 hours) and specificity (24/36 hours) for the prediction of poor CPC at 24 and 48 hours were 0.221/0.249 ug/L, 75/65% and 82.4/94.1%, respectively. Conclusions: Serum S-100B protein was an early and useful marker for the prediction of poor neurological outcomes in post-CA patients treated with TH and the optimal sampling times were 24 and 36 hours after ROSC. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한중환자의학회 | - |
dc.relation.isPartOf | Acute and Critical Care | - |
dc.title | Prognostic Value and Optimal Sampling Time of S-100B Protein for Outcome Prediction in Cardiac Arrest Patients Treated with Therapeutic Hypothermia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | Acute and Critical Care, v.29, no.4, pp.304 - 312 | - |
dc.identifier.kciid | ART001931053 | - |
dc.citation.endPage | 312 | - |
dc.citation.startPage | 304 | - |
dc.citation.title | Acute and Critical Care | - |
dc.citation.volume | 29 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | 김형석 | - |
dc.contributor.affiliatedAuthor | 정호성 | - |
dc.contributor.affiliatedAuthor | 임용수 | - |
dc.contributor.affiliatedAuthor | 우재혁 | - |
dc.contributor.affiliatedAuthor | 장재호 | - |
dc.contributor.affiliatedAuthor | 장지용 | - |
dc.contributor.affiliatedAuthor | 양혁준 | - |
dc.subject.keywordAuthor | cardiac arrest | - |
dc.subject.keywordAuthor | hypothermia | - |
dc.subject.keywordAuthor | S100 calcium binding protein beta subunit | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
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