鼻皮 증류액의 항균, 소염, 항산화 작용에 대한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김호선 | - |
dc.contributor.author | 이영종 | - |
dc.date.available | 2020-02-28T20:41:19Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1229-1765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13441 | - |
dc.description.abstract | Objectives : The purpose of the study is to test the antibacterial, anti-inflammatory and antioxidant effects of BPH, which is composed of Pini Densiflorae Nodi Lignum and Querci Acutissimae Fructus, Angelicae Gigantis Radix, Cnidii Rhizoma, Angelicae Dahuricae Radix, Angelicae Tenuissimae Radix. Method : Antibacterial and anti-inflammatory effects of BPH on Propionibacterium acnes, one of anaerobic bacteria species were evaluated by measuring the levels of 2,2-diphenyl-1-picrylhydrazyl (DPPH) elimination and lipid peroxidation. Result : When BPH was applied to CCD-986sk (Human normal fibroblast) to confirm the level of cytokine(tumor necrosis factor-alpha, interleukin-8), its level increased in proportion to that of BPH's concentration, which indicated dose-dependent relationship. Using the Disk diffusion to measure the bacterial growth inhibition zone varying BPH concentration, it was found that the antibacterial effect of BPH was less than that of erythromycin, the control group, but was higher than that of saline, and it increased with higher concentrations. In a liquid culture medium containing BPH, the growth rate of Propionibacterium acnes was decreased by more than 10% at 25% BPH. After adding P. acnes to THP-1 monocyte, and treated it with BPH, and measuring the concentration of TNF-a and IL-8, it was observed that the amount of TNF-a and IL-8 significantly decreased depending on the level of BPH concentration. The ability to eliminate DPPH increased with higher BPH concentration. The inhibition of lipid peroxidation was increased by BHT treatment in a dose-dependent manner. Conclusion : Using Propionibacterium acnes, an anaerobic bacteria, we confirmed that BPH has antibacterial, anti-inflammatory and antioxidant effects. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한본초학회 | - |
dc.relation.isPartOf | 대한본초학회지 | - |
dc.title | 鼻皮 증류액의 항균, 소염, 항산화 작용에 대한 연구 | - |
dc.title.alternative | Studies on the Anti-bacterial, Anti-inflammatory and Anti-oxidant Effect of BPH | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한본초학회지, v.29, no.5, pp.45 - 53 | - |
dc.identifier.kciid | ART001915618 | - |
dc.citation.endPage | 53 | - |
dc.citation.startPage | 45 | - |
dc.citation.title | 대한본초학회지 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | 김호선 | - |
dc.contributor.affiliatedAuthor | 이영종 | - |
dc.subject.keywordAuthor | BPH | - |
dc.subject.keywordAuthor | THP-1 | - |
dc.subject.keywordAuthor | CCD-986sk | - |
dc.subject.keywordAuthor | anti-bacteria | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | anti-oxidation | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.