黃連 추출물의 항염효능에 관한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이전우 | - |
dc.contributor.author | 한효상 | - |
dc.contributor.author | 이영종 | - |
dc.date.available | 2020-02-28T20:41:20Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1229-1765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13442 | - |
dc.description.abstract | Objectives : This research has been done to investigate the anti-inflammatory effect of Coptidis Rhizoma extracts. Method : Coptidis Rhizoma was extracted by 100℃ water. The extract (CC : Extract of Coptis chinensis rhizome) was used to examine its effects on the cell viability of mouse macrophage Raw 264.7 cell line. Also the production of nitric oxide (NO), the c-jun N-terminalkinase (JNK) activation and the production of cytokines such as (IL)-5 were evaluated in lipopolysaccharide (LPS)-stimulated Raw 264.7 cells. After the CC and LPS were applied to Raw 264.7 cells which were cultured for 24 hours, the MTT assay was performed. Result : The CC extracts didn't affect the viability of macrophage cells. However, the extracts inhibited the NO production and the JNK activation significantly in LPS-stimulated macrophage cells treated with 100 and 200 ㎍/mL concentrations. The CC extract, also, impeded the production of inflammation-related factors and cytokines such as KC, VEGF, MCP-1, GM-CSF, IL-1α, IL-5, IL-6, and IL-12p40 in LPS-stimulated macrophage cells at the concentration higher than 25 ㎍/mL. The production of basic-FGF concentration of 50 and 100 ㎍/mL, the production of IP-10 at 100 ㎍/mL, and the production of IFN-γ at 25 ㎍/mL, respectively. Conclusion : The CC prepared using 100℃ water showed the significant anti-inflammatory effect such as the inhibition not only on the production of NO, KC, VEGF, MCP-1, GM-CSF, IL-1α, IL-5, IL-6, and IL-12p40 in LPS-stimulated macrophage cells at or higher than the concentration of 25 ㎍/mL, but also on the JNK activation at 100 and 200 ㎍/mL. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한본초학회 | - |
dc.relation.isPartOf | 대한본초학회지 | - |
dc.title | 黃連 추출물의 항염효능에 관한 연구 | - |
dc.title.alternative | Anti-inflammatory Effect of Coptidis Rhizoma Extract | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한본초학회지, v.29, no.5, pp.83 - 90 | - |
dc.identifier.kciid | ART001915622 | - |
dc.citation.endPage | 90 | - |
dc.citation.startPage | 83 | - |
dc.citation.title | 대한본초학회지 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | 이전우 | - |
dc.contributor.affiliatedAuthor | 이영종 | - |
dc.subject.keywordAuthor | Coptidis Rhizoma | - |
dc.subject.keywordAuthor | macrophage cells | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | JNK | - |
dc.description.journalRegisteredClass | kci | - |
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