導痰湯이 고지혈증 흰쥐의 뇌허혈 손상에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경훈 | - |
dc.contributor.author | 김도훈 | - |
dc.contributor.author | 김연섭 | - |
dc.date.available | 2020-02-28T20:41:22Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1229-1765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13444 | - |
dc.description.abstract | Objectives : Dodam-tang has been reported to have a control effect against the hyperlipidemia and thrombosis. Based upon these previous reports, this study investigates the effects of Dodam-tang on the cerebral ischemic damage of the hyperlipidemic rats. Methods : Hyperlipidemia was induced by the beef tallow 30% diet for 14 days on Sprague-Dawley rats. Ischemic damage was induced by the middle cerebral artery occlusion (MCAO) for 2 hours with the intraluminal thread method. Then water extract of Dodam-tang was administered daily for 5 days. The effect of Dodam-tang was evaluated with the serum lipids, infarct volume and edema percentage, and immunohistochemical expressions of iNOS, MMP-9, and GFAP in the brain tissue. Results : The obtained results were as follows; Dodam-tang reduced significantly the infarct size in a TTC-stained 5th brain section of the hyperlipidemic MCAO rats. Dodam-tang suppressed the infarct volume of the hyperlipidemic MCAO rats, but not significant statistically. Dodam-tang suppressed the edema percentage of the hyperlipidemic MCAO rats significantly in the brain tissue. Dodam-tang suppressed significantly the iNOS expression in the cerebral penumbra and caudate putamen of the hyperlipidemic MCAO rats. Dodam-tang suppressed significantly the MMP-9 expression in the cerebral penumbra of the hyperlipidemic MCAO rats. Dodam-tang suppressed significantly the GFAP-expressed atrocytes in the cerebral penumbra of the hyperlipidemic MCAO rats. Conclusions : These results suggest that Dodam-tang suppresses the brain edema formation through the suppression of the iNOS, MMP-9 and GFAP, but the neuroprotective effect against the cerebral infarct are not distinct. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한본초학회 | - |
dc.relation.isPartOf | 대한본초학회지 | - |
dc.title | 導痰湯이 고지혈증 흰쥐의 뇌허혈 손상에 미치는 영향 | - |
dc.title.alternative | Effects of Dodam-tang on Cerebral Ischemic Damage of Hyperlipidemic Rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한본초학회지, v.29, no.5, pp.23 - 30 | - |
dc.identifier.kciid | ART001915615 | - |
dc.citation.endPage | 30 | - |
dc.citation.startPage | 23 | - |
dc.citation.title | 대한본초학회지 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | 김경훈 | - |
dc.contributor.affiliatedAuthor | 김도훈 | - |
dc.contributor.affiliatedAuthor | 김연섭 | - |
dc.subject.keywordAuthor | Dodam-tang | - |
dc.subject.keywordAuthor | iNOS | - |
dc.subject.keywordAuthor | MMP-9 | - |
dc.subject.keywordAuthor | GFAP | - |
dc.subject.keywordAuthor | edema | - |
dc.subject.keywordAuthor | neuroprotective effect | - |
dc.description.journalRegisteredClass | kci | - |
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