LPS로 유발된 우울증에 대한 甘草의 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고성렬 | - |
dc.contributor.author | 김도훈 | - |
dc.contributor.author | 이태희 | - |
dc.date.available | 2020-02-28T20:41:28Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1229-1765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13451 | - |
dc.description.abstract | Objectives : Investigation of the antidepressant effect of Glycyrrhizae Radix (GR) through the anti-inflammatory effect. Methods : Depression in rats was induced by LPS (i,p.3days). The rats were treated with GR100 mg/kg (GR 100) or GR400 mg/kg (GR 400). The depressive immobility was examined with Tail Suspension Test(TST) and Forced Swimming Test(FST). The expression of nuclear factor-κB(NF-κB), IκB was measured with western blotting. The concentration of corticosterone, cytokine in plasma was measured with ELISA. The expression of c-Fos in the paraventricular nucleus(PVN) and tyrosine hydroxylase(TH) in the locus coeluleus(LC) were measured with immunostaining method. Results : In the TST, GR400 group significantly decreased immobility time compared with the LPS group. In the FST, GR100, GR400 group significantly decreased immobility time comparing with the LPS group. c-Fos expression in GR100 and GR400 group was decreased comparing with the lipoplysaccharide(LPS) group. The IκB expression of GR100 and GR400 group was increased comparing with the LPS group. The level of corticosterone of GR100 group was decreased comparing with the LPS group. The concentration of cytokine of GR100 and GR400 group was decreased comparing with the LPS group. TH expression in the LC was increased in LPS group, but in GR100 and GR400 group was not shown significant decrease. Conclusion : According to this results obtained, GR has antidepressant effects by the anti inflammatory action through the suppression of HPA axis activity, not through the aciton against the catecholaminergic system. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한본초학회 | - |
dc.relation.isPartOf | 대한본초학회지 | - |
dc.title | LPS로 유발된 우울증에 대한 甘草의 효과 | - |
dc.title.alternative | Effect of Glycyrrhizae Radix Water Extract on the depression induced by LPS in Rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한본초학회지, v.29, no.5, pp.9 - 16 | - |
dc.identifier.kciid | ART001915613 | - |
dc.citation.endPage | 16 | - |
dc.citation.startPage | 9 | - |
dc.citation.title | 대한본초학회지 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | 고성렬 | - |
dc.contributor.affiliatedAuthor | 김도훈 | - |
dc.contributor.affiliatedAuthor | 이태희 | - |
dc.subject.keywordAuthor | Glycyrrhizae Radix(GR) | - |
dc.subject.keywordAuthor | LPS | - |
dc.subject.keywordAuthor | HPA axis | - |
dc.subject.keywordAuthor | anti-inflamation. anti-depressant effect. | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.