Antibacterial Activity of Chitosan against Antibiotics Resistance Bacteria in Porcine Semen

Abstract

Bacteria in porcine semen having resistance on antibiotics decrease the quality and viability of sperms. In the continuingsearch for potential antibacterial of chitosan with different molecular weight, we have isolated bacterial strain from porcinesemen and applied chitosan to address their antibacterial activity. However, definitive evidence for this relationship betweendifferent molecular weight chitosan and its antibacterial activity toward some bacterial strains in porcine semen was in lacking. The results showed that no significant synergic effects of chitosan with different molecular weight with antibiotics on bacteriaisolated from two different sources of semen were observed. However all chitosan and glucosamine used in this study showedantibacterial activity toward ARB, which showed the resistance especially toward ampicillin and erythromycin. Our data suggestthat chitosan can be used as potential therapeutic agents in the treatment of porcine semen that could specifically targetantibiotics resistance bacterial cells (ARB).