Postnatal treadmill exercise alleviates short-term memory impairment by enhancing cell proliferation and suppressing apoptosis in the hippocampus of rat pups born to diabetic rats
- Authors
- 김영훈; 성윤희; 이희혁; 고일규; 김성은; 신말순; 김보균
- Issue Date
- 2014
- Publisher
- 한국운동재활학회
- Keywords
- Diabetic rats; Treadmill exercise; Cell proliferation; Apopto-sis; Rat pups; Hippocampal dentate gyrus
- Citation
- Journal of exercise rehabilitation, v.10, no.4, pp.209 - 217
- Journal Title
- Journal of exercise rehabilitation
- Volume
- 10
- Number
- 4
- Start Page
- 209
- End Page
- 217
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13539
- DOI
- 10.12965/jer.140145
- ISSN
- 2288-176X
- Abstract
- During pregnancy, diabetes mellitus exerts detrimental effects on the development of the fetus, especially the central nervous system. In the current study, we evaluated the effects of postnatal treadmill exercise on short-term memory in relation with cell proliferation and apoptosis in the hippocampus of rat pups born to streptozotocin (STZ)-induced dia-betic maternal rats. Adult female rats were mated with male rats for 24 h. Two weeks after mating, the pregnant female rats were divided into two groups: control group and STZ injection group. The pregnant rats in the STZ injection group were administered 40 mg/kg of STZ intraperito-neally. After birth, the rat pups were divided into the following four groups: control group, control with postnatal exercise group, maternal STZ-in-jection group, and maternal STZ-injection with postnatal exercise group. The rat pups in the postnatal exercise groups were made to run on a treadmill for 30 min once a day, 5 times per week for 2 weeks beginning 4 weeks after birth. The rat pups born to diabetic rats were shown to have short-term memory impairment with suppressed cell proliferation and increased apoptosis in the hippocampal dentate gyrus. Postnatal treadmill exercise alleviated short-term memory impairment by increased cell proliferation and suppressed apoptosis in the rat pups born to dia-betic rats. These findings indicate that postnatal treadmill exercise may be used as a valuable strategy to ameliorate neurodevelopmental prob-lems in children born to diabetics.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13539)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.