Inhibitory Effect of Bee Venom Toxin on the Growth of Cervix Cancer C33A Cells via Death Receptor Expression and Apoptosis
DC Field | Value | Language |
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dc.contributor.author | 고성철 | - |
dc.contributor.author | 송호섭 | - |
dc.date.available | 2020-02-28T20:44:55Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2586-288X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13678 | - |
dc.description.abstract | Objectives : We investigated whether bee venom(BV) inhibit cell growth through enhancement of death receptor expressions in the human cervix cancer C33A cells. Methods : BV(1~5 ㎍/㎖) inhibited the growth of cervix cancer C33A cells by the induction of apoptotic cell death in a dose dependent manner. Results : Consistent with apoptotic cell death, expression of Fas, death receptor(DR) 3, 4, 5 and 6 was increased concentration dependently in the cells. Moreover, Fas, DR3 and DR6 revealed more sensitivity to BV. Thus, We reconfirmed whether they actually play a critical role in anti-proliferation of cervix cancer C33A cells. Consecutively, expression of DR downstream pro-apoptotic proteins including caspase-8, -3, -9 was upregulated and Bax was concomitantly overwhelmed the expression of Bcl-2. NF-κB were also inhibited by treatment with BV in C33A cells. Conclusions : These results suggest that BV could exert anti-tumor effect through induction of apoptotic cell death in human cervix cancer C33A cells via enhancement of death receptor expression, and that BV could be a promising agent for preventing and treating cervix cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한침구의학회 | - |
dc.relation.isPartOf | Journal of Acupuncture Research | - |
dc.title | Inhibitory Effect of Bee Venom Toxin on the Growth of Cervix Cancer C33A Cells via Death Receptor Expression and Apoptosis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | Journal of Acupuncture Research, v.31, no.2, pp.75 - 85 | - |
dc.identifier.kciid | ART001882306 | - |
dc.citation.endPage | 85 | - |
dc.citation.startPage | 75 | - |
dc.citation.title | Journal of Acupuncture Research | - |
dc.citation.volume | 31 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | 고성철 | - |
dc.contributor.affiliatedAuthor | 송호섭 | - |
dc.subject.keywordAuthor | Bee venom | - |
dc.subject.keywordAuthor | Cervix cancer | - |
dc.subject.keywordAuthor | C33A | - |
dc.subject.keywordAuthor | Death receptor | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.description.journalRegisteredClass | kci | - |
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