Effect of Chitosan and Curcumin Complex on the Full-thickness Skin Wound Healing in Rabbits

Abstract

The purpose of this study was to examine the effect of Chitosan-curcumin (CTSN-cur) complex on the full-thickness skinwound healing in rabbits. Five healthy adult New Zealand rabbit were used and 4 full thickness skin defects were made in thedorsal skin of the trunk. The experimental groups were divided according to the applied materials: control group; salinetreatment, hyaluronic acid (HA) group; 0.5% HA treatment, CTSN Group; 0.5% CTSN treatment, CTSN-cur group; 0.5%CTSN-cur complex treatment. Biopsy was performed immediately after euthanasia on day 14. This study showed that moresignificant accelerating effects on the full-thickness wound healings were detected in CTSN-cur applied wounds as comparedwith other treated wounds. CTSN-cur applied wounds showed more rapid wound contraction, more rapid reconstruction ofgranulation tissues such as increase of re-epithelization rates, less neovascularization, less inflammatory cell infiltrations, morerapid collagen fiber regenerations, and decrease of granulation tissues area as compared with other treated wounds. Therefore, itwas concluded that CTSN-cur may be useful as a wound healing regulator for the treatment of skin wound defects.