Inhibitory Effect of Bee Venom Toxin on Lung Cancer NCI H460 Cells Growth Through Induction of Apoptosis via Death Receptor Expressions
- Authors
- Keun Young Hur; 송호섭
- Issue Date
- 2014
- Publisher
- 대한침구의학회
- Keywords
- Bee venom; Lung cancer; NCI-H460; Death receptor; Apoptosis
- Citation
- Journal of Acupuncture Research, v.31, no.1, pp.121 - 130
- Journal Title
- Journal of Acupuncture Research
- Volume
- 31
- Number
- 1
- Start Page
- 121
- End Page
- 130
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13965
- ISSN
- 2586-288X
- Abstract
- Objectives : I investigated whether bee venom inhibit cell growth through enhancement of death receptor expressions in the human lung cancer cells, NCI-H460.
Methods : Bee venom(1-5 μg/ml) inhibited the growth of NCI-H460 lung cancer cells by the induction of apoptotic cell death in a dose dependent manner.
Results : Consistent with apoptotic cell death, expression of TNF-R1, TNF-R2, FAS, death receptors(DR) 3, 4, 5 and 6 was increased in the cells. Expression of DR downstream pro-apoptotic proteins including Caspase-8, -3, -9 was upregulated and Bax was concomitantly overwhelmed the expression of Bcl-2. NF-kB were inhibited by treatment with bee venom in NCI-H460 cells through TNF response change led by TNF-R1 and TNF-R2.
Conclusions : These results suggest that bee venom should exert anti-tumor effect through induction of apoptotic cell death in NCI-H460 human lung cancer cells via enhancement of death receptor expression, and that bee venom could be a promising agent for preventing and treating lung cancer.
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Collections - 한의과대학 > 한의학과 > 1. Journal Articles
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