Herbal Prescription, DSGOST, Prevents Cold-Induced RhoA Activation and Endothelin-1 Production in Endothelial Cells
DC Field | Value | Language |
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dc.contributor.author | Cho, Sung-Gook | - |
dc.contributor.author | Go, Ho Yeon | - |
dc.contributor.author | Park, Jeong-Su | - |
dc.contributor.author | Jung, Ki-Yong | - |
dc.contributor.author | Sun, Seung-Ho | - |
dc.contributor.author | Choi, You-Kyung | - |
dc.contributor.author | Song, Yun-Kyung | - |
dc.contributor.author | Park, Jong-Hyeong | - |
dc.contributor.author | Jun, Chan-Yong | - |
dc.contributor.author | Ko, Seong Gyu | - |
dc.date.available | 2020-02-28T21:45:35Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14002 | - |
dc.description.abstract | Herbal prescription, Danggui-Sayuk-Ga-Osuyu-Saenggang-tang (DSGOST), has long been used to treat Raynaud's phenomenon (RP) in traditional Chinese medicine (TCM). However, a biological mechanism by which DSGOST ameliorates RP is yet deciphered. In this study, we demonstrate that DSGOST inhibits cold-induced activation of RhoA, in both vascular smooth-muscle cells (VSMC) and endothelial cells (EC), and blocks endothelin-1-mediated paracrine path for cold response on vessels. While cold induced RhoA activity in both cell types, DSGOST pretreatment prevented cold-induced RhoA activation. DSGOST inhibition of cold-induced RhoA activation further blocked. alpha 2c-adrenoreceptor translocation to the plasma membrane in VSMC. In addition, DSGOST inhibited endothelin-1-mediated RhoA activation and. alpha 2c-adrenoreceptor translocation in VSMC. Meanwhile, DSGOST inhibited cold-induced or RhoA-dependent phosphorylation of FAK, SRC, and ERK. Consistently, DSGOST inhibited cold-induced endothelin-1 expression in EC. Therefore, DSGOST prevents cold-induced RhoA in EC and blocks endothelin-1-mediated paracrine path between EC and VSMC. In conclusion, our data suggest that DSGOST is beneficial for treating RP-like syndrome. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.relation.isPartOf | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.subject | INHIBITS TUMOR ANGIOGENESIS | - |
dc.subject | SMOOTH-MUSCLE | - |
dc.subject | INDUCED VASOCONSTRICTION | - |
dc.subject | INDUCED CONSTRICTION | - |
dc.subject | RAYNAUDS-PHENOMENON | - |
dc.subject | KINASE | - |
dc.subject | PROGRESSION | - |
dc.subject | EXPRESSION | - |
dc.subject | CYTOKINES | - |
dc.title | Herbal Prescription, DSGOST, Prevents Cold-Induced RhoA Activation and Endothelin-1 Production in Endothelial Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000335160100001 | - |
dc.identifier.doi | 10.1155/2014/549307 | - |
dc.identifier.bibliographicCitation | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.identifier.scopusid | 2-s2.0-84900333108 | - |
dc.citation.title | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.contributor.affiliatedAuthor | Park, Jeong-Su | - |
dc.contributor.affiliatedAuthor | Jung, Ki-Yong | - |
dc.contributor.affiliatedAuthor | Choi, You-Kyung | - |
dc.contributor.affiliatedAuthor | Song, Yun-Kyung | - |
dc.contributor.affiliatedAuthor | Park, Jong-Hyeong | - |
dc.contributor.affiliatedAuthor | Jun, Chan-Yong | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INHIBITS TUMOR ANGIOGENESIS | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE | - |
dc.subject.keywordPlus | INDUCED VASOCONSTRICTION | - |
dc.subject.keywordPlus | INDUCED CONSTRICTION | - |
dc.subject.keywordPlus | RAYNAUDS-PHENOMENON | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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