Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Byoung-Joon | - |
dc.contributor.author | Akbar, Mohammed | - |
dc.contributor.author | Abdelmegeed, Mohamed A. | - |
dc.contributor.author | Byun, Kyunghee | - |
dc.contributor.author | Lee, Bonghee | - |
dc.contributor.author | Yoon, Seung Kew | - |
dc.contributor.author | Hardwick, James P. | - |
dc.date.available | 2020-02-28T22:41:30Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 2213-2317 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14029 | - |
dc.description.abstract | Mitochondria are critically important in providing cellular energy ATP as well as their involvement in anfi-oxiclant defense, fat oxidation, intermediary metabolism and cell death processes lt is well-established that mitochondrial functions are suppressed when living cells or organisms are exposed to potentially toxic agents including alcohol, high fat diets, smoking and certain drugs or in many pathophysiological states through increased levels of oxidative/nitrative stress. Under elevated nitroxidative stress, cellular macromolecules proteins, DNA, and lipids can undergo different oxidative modifications, leading to disruption of their normal, sometimes critical, physiological functions. Recent reports also indicated that many mitochondrial proteins are modified via various post-translation modifications (PTMs) and primarily inactivated. Because of the recently-emerging information, in this review, we specifically focus on the mechanisms and roles of five major PTMs (namely oxidation, nitration, phosphorylation, acetylation, and adduct formation with lipid-peroxides, reactive metabolites, or advanced glycation end products) in experimental models of alcoholic and nonalcoholic fatty liver disease as well as acute hepatic injury caused by toxic compounds. We also highlight the role of the ethanol-inducible cytochrome P450-2E1 (CYP2E1) in some of these PTM changes. Finally, we discuss translational research opportunities with natural and/or synthetic anti-oxidants, which can prevent or delay the onset of mitochondial dysfunction, fat accumulation and tissue injury. Published by Elsevier B.V. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.relation.isPartOf | REDOX BIOLOGY | - |
dc.title | Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000350812500014 | - |
dc.identifier.doi | 10.1016/j.redox.2014.10.004 | - |
dc.identifier.bibliographicCitation | REDOX BIOLOGY, v.3, pp.109 - 123 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84918551836 | - |
dc.citation.endPage | 123 | - |
dc.citation.startPage | 109 | - |
dc.citation.title | REDOX BIOLOGY | - |
dc.citation.volume | 3 | - |
dc.contributor.affiliatedAuthor | Byun, Kyunghee | - |
dc.contributor.affiliatedAuthor | Lee, Bonghee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Nitroxidative stress | - |
dc.subject.keywordAuthor | Redox | - |
dc.subject.keywordAuthor | Post-translational modifications | - |
dc.subject.keywordAuthor | Mitochondrial proteins | - |
dc.subject.keywordAuthor | Mitochondrial dysfunction | - |
dc.subject.keywordAuthor | Tissue injury | - |
dc.subject.keywordPlus | INDUCED LIVER-INJURY | - |
dc.subject.keywordPlus | NADP(+)-DEPENDENT ISOCITRATE DEHYDROGENASE | - |
dc.subject.keywordPlus | CYTOCHROME-C-OXIDASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | TERMINAL KINASE | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | ALDEHYDE DEHYDROGENASE | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.