Effect of Sipjeondaebo-Tang on Cancer-Induced Anorexia and Cachexia in CT-26 Tumor-Bearing Mice
DC Field | Value | Language |
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dc.contributor.author | Choi, Youn Kyung | - |
dc.contributor.author | Jung, Ki Yong | - |
dc.contributor.author | Woo, Sang-Mi | - |
dc.contributor.author | Yun, Yee Jin | - |
dc.contributor.author | Jun, Chan-Yong | - |
dc.contributor.author | Park, Jong Hyeong | - |
dc.contributor.author | Shin, Yong Cheol | - |
dc.contributor.author | Cho, Sung-Gook | - |
dc.contributor.author | Ko, Seong-Gyu | - |
dc.date.available | 2020-02-28T22:41:42Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0962-9351 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14040 | - |
dc.description.abstract | Cancer-associated anorexia and cachexia are amultifactorial condition described by a loss of body weight and muscle with anorexia, asthenia, and anemia. Moreover, they correlate with a high mortality rate, poor response to chemotherapy, poor performance status, and poor quality of life. Cancer cachexia is regulated by proinflammatory cytokines such as interleukin- 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor-alpha (TNF-alpha). In addition, glucagon like peptide-1 (GIP-1), peptide YY (PYY), ghrelin, and leptin plays a crucial role in food intake. In this study, we investigated the therapeutic effects of one of the traditional herbal medicines, Sipjeondaebo-tang (Juzen-taiho-to in Japanese; SJDBT), on cancer anorexia and cachexia in a fundamental mouse cancer anorexia/cachexia model, CT-26 tumor-bearing mice. SJDBT was more significantly effective in a treatment model where it was treated after anorexia and cachexia than in a prevention model where it was treated before anorexia and cachexia on the basis of parameters such as weights of muscles and whole body and food intakes. Moreover, SJDBT inhibited a production of IL-6, MCP-1, PYY, and GLP-1 and ameliorated cancer-induced anemia. Therefore, our in vivo studies provide evidence on the role of SJDBT in cancer-associated anorexia and cachexia, thereby suggesting that SJDBT may be useful for treating cancer-associated anorexia and cachexia. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI PUBLISHING CORPORATION | - |
dc.relation.isPartOf | MEDIATORS OF INFLAMMATION | - |
dc.subject | JUZEN-TAIHO-TO | - |
dc.subject | JAPANESE HERBAL MEDICINE | - |
dc.subject | TRADITIONAL CHINESE-MEDICINE | - |
dc.subject | WEIGHT-LOSS | - |
dc.subject | FOOD-INTAKE | - |
dc.subject | BODY-WEIGHT | - |
dc.subject | CELLS | - |
dc.subject | LEPTIN | - |
dc.subject | INTERLEUKIN-6 | - |
dc.subject | SECRETION | - |
dc.title | Effect of Sipjeondaebo-Tang on Cancer-Induced Anorexia and Cachexia in CT-26 Tumor-Bearing Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000336284100001 | - |
dc.identifier.doi | 10.1155/2014/736563 | - |
dc.identifier.bibliographicCitation | MEDIATORS OF INFLAMMATION | - |
dc.identifier.scopusid | 2-s2.0-84901812850 | - |
dc.citation.title | MEDIATORS OF INFLAMMATION | - |
dc.contributor.affiliatedAuthor | Jung, Ki Yong | - |
dc.contributor.affiliatedAuthor | Jun, Chan-Yong | - |
dc.contributor.affiliatedAuthor | Park, Jong Hyeong | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | JUZEN-TAIHO-TO | - |
dc.subject.keywordPlus | JAPANESE HERBAL MEDICINE | - |
dc.subject.keywordPlus | TRADITIONAL CHINESE-MEDICINE | - |
dc.subject.keywordPlus | WEIGHT-LOSS | - |
dc.subject.keywordPlus | FOOD-INTAKE | - |
dc.subject.keywordPlus | BODY-WEIGHT | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | LEPTIN | - |
dc.subject.keywordPlus | INTERLEUKIN-6 | - |
dc.subject.keywordPlus | SECRETION | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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