Lupeol Is One of Active Components in the Extract of Chrysanthemum indicum Linne That Inhibits LMP1-Induced NF-kappa B Activation
- Authors
- Kang, Se Chan; Lim, Sue Yeon; Song, Yoon-Jae
- Issue Date
- Nov-2013
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v.8, no.11
- Journal Title
- PLOS ONE
- Volume
- 8
- Number
- 11
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14117
- DOI
- 10.1371/journal.pone.0082688
- ISSN
- 1932-6203
- Abstract
- We have previously reported that seventy percent ethanol extract of Chrysanthemum indicum Linne (CIE) strongly reduces Epstein-Barr virus (EBV)-transformed lymphoblastoid cell line (LCL) survival by inhibiting virus-encoded latent infection membrane protein 1 (LMP1)-induced NF-kappa B activation. To identify an active compound(s) in CIE that inhibits LMP1-induced NF-kappa B activation, activity-guided fractionation was employed. The CH2Cl2 fraction of CIE strongly reduced LMP1-induced NF-kappa B activation and LCL viability with relatively low cytotoxic effects on primary human foreskin fibroblast (HFF), HeLa or Burkitt's lymphoma (BL41) cells. Furthermore, lupeol, a pentacyclic triterpene, was identified in the CH2Cl2 fraction of CIE to attenuate LMP1-induced NF-kappa B activation and LCL viability. This study demonstrates that lupeol is one of active compounds in the CH2Cl2 fraction of CIE that inhibits LMP1-induced NF-kappa B activation and reduces NF-kappa B-dependent LCL viability.
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Collections - 바이오나노대학 > 생명과학과 > 1. Journal Articles
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