2,4-Di-tert-butylphenol from Sweet Potato Protects Against Oxidative Stress in PC12 Cells and in Mice
DC Field | Value | Language |
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dc.contributor.author | Choi, Soo Jung | - |
dc.contributor.author | Kim, Jae Kyeom | - |
dc.contributor.author | Kim, Hye Kyung | - |
dc.contributor.author | Harris, Keith | - |
dc.contributor.author | Kim, Chang-Ju | - |
dc.contributor.author | Park, Gwi Gun | - |
dc.contributor.author | Park, Cheung-Seog | - |
dc.contributor.author | Shin, Dong-Hoon | - |
dc.date.available | 2020-02-28T22:43:10Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-11-01 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14124 | - |
dc.description.abstract | In this study, the protective effect of sweet potato extract against hydrogen peroxide-induced oxidative stress and cytotoxicity on the pheochromocytoma cell line (PC12) was investigated. The active component of the sweet potato extract was purified and determined to be 2,4-di-tert-butylphenol. The antioxidant capacity of 2,4-di-tert-butylphenol was measured by using 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) radical. To examine the effects of 2,4-di-tert-butylphenol on amyloid-beta peptide (A(1-42))-induced learning and memory impairment in mice, in vivo behavioral tests were performed. Administration of 2,4-di-tert-butylphenol increased alternation behavior in mice injected with A(1-42). These results suggest that sweet potato extract could be protective against A-induced neurotoxicity, possibly due to the antioxidative capacity of its constituent, 2,4-di-tert-butylphenol. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.subject | ALZHEIMERS-DISEASE BRAIN | - |
dc.subject | PHENOLIC PHYTOCHEMICALS | - |
dc.subject | ANTIOXIDANT ACTIVITIES | - |
dc.subject | DIETARY ANTIOXIDANTS | - |
dc.subject | HYDROXYL RADICALS | - |
dc.subject | MECHANISMS | - |
dc.subject | APOPTOSIS | - |
dc.title | 2,4-Di-tert-butylphenol from Sweet Potato Protects Against Oxidative Stress in PC12 Cells and in Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000327026500003 | - |
dc.identifier.doi | 10.1089/jmf.2012.2739 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.16, no.11, pp.977 - 983 | - |
dc.identifier.kciid | ART001822678 | - |
dc.identifier.scopusid | 2-s2.0-84887855287 | - |
dc.citation.endPage | 983 | - |
dc.citation.startPage | 977 | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 16 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Park, Gwi Gun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | amyloid beta peptide | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | PC12 cells | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE BRAIN | - |
dc.subject.keywordPlus | PHENOLIC PHYTOCHEMICALS | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITIES | - |
dc.subject.keywordPlus | DIETARY ANTIOXIDANTS | - |
dc.subject.keywordPlus | HYDROXYL RADICALS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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