Outcomes of ovarian preservation in a cohort of premenopausal women with early-stage endometrial cancer: A Korean Gynecologic Oncology Group study
DC Field | Value | Language |
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dc.contributor.author | Lee, Taek Sang | - |
dc.contributor.author | Lee, Jung-Yun | - |
dc.contributor.author | Kim, Jae-Weon | - |
dc.contributor.author | Oh, Sohee | - |
dc.contributor.author | Seong, Seok Ju | - |
dc.contributor.author | Lee, Jong Min | - |
dc.contributor.author | Kim, Tae Jin | - |
dc.contributor.author | Cho, Chi Heum | - |
dc.contributor.author | Kim, Seok-Mo | - |
dc.contributor.author | Park, Chan-Yong | - |
dc.date.available | 2020-02-28T22:43:25Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14142 | - |
dc.description.abstract | Objective. The aim of this study was to evaluate the impact of ovarian preservation on the recurrence and survival rates of premenopausal women with early-stage endometrial cancer. Methods. Using medical records of premenopausal women who received primary surgical treatment for stage I-II endometrial cancer, the demographics and survival rates were compared retrospectively for patients who had ovarian preservation and those who underwent bilateral salpingo-oophorectomy. Cox proportional hazards models with inverse probability of treatment weighting (IPTW) based on propensity score were performed to adjust for selection bias between the two groups. Results. A total of 495 women were identified, including 176 patients who had ovarian preservation. The ovarian preservation group was younger (P < 0.001) and had an earlier year of diagnosis (P = 0.014), a lower prevalence of lymphadenectomy (P < 0.001), and a marginally significant association with lower tumor grade (P = 0.052). The Kaplan-Meier curve and the log rank test showed no difference in either recurrence-free survival (P = 0.742) or overall survival (P = 0.462) between the two groups. In a multivariate Cox model adjusted by IPTW and covariates, ovarian preservation had no effect on either recurrence (hazard ratio [HR], 0.73; 95% CI, 0.29-1.81) or overall survival (HR, 1.33; 95% CI, 0.43-4.09). Conclusions. Ovarian preservation does not appear to be associated with an adverse impact on the outcomes of premenopausal women with early-stage endometrial cancer. The present study has useful implications for physicians counseling young women who want to preserve their ovaries. (C) 2013 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | GYNECOLOGIC ONCOLOGY | - |
dc.subject | ESTROGEN REPLACEMENT THERAPY | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | YOUNG-WOMEN | - |
dc.subject | CARCINOMA | - |
dc.subject | OOPHORECTOMY | - |
dc.subject | SURVIVAL | - |
dc.subject | AGE | - |
dc.subject | METASTASIS | - |
dc.subject | STATISTICS | - |
dc.subject | MALIGNANCY | - |
dc.title | Outcomes of ovarian preservation in a cohort of premenopausal women with early-stage endometrial cancer: A Korean Gynecologic Oncology Group study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000326427900002 | - |
dc.identifier.doi | 10.1016/j.ygyno.2013.08.024 | - |
dc.identifier.bibliographicCitation | GYNECOLOGIC ONCOLOGY, v.131, no.2, pp.289 - 293 | - |
dc.identifier.scopusid | 2-s2.0-84886101082 | - |
dc.citation.endPage | 293 | - |
dc.citation.startPage | 289 | - |
dc.citation.title | GYNECOLOGIC ONCOLOGY | - |
dc.citation.volume | 131 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Park, Chan-Yong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Endometrial cancer | - |
dc.subject.keywordAuthor | Ovarian preservation | - |
dc.subject.keywordAuthor | Premenopausal women | - |
dc.subject.keywordPlus | ESTROGEN REPLACEMENT THERAPY | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | YOUNG-WOMEN | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | OOPHORECTOMY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | STATISTICS | - |
dc.subject.keywordPlus | MALIGNANCY | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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