Bioactive Sesquiterpenes from the Essential Oil of Thuja orientalis
DC Field | Value | Language |
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dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Moon, Eunjung | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Son, Mi Won | - |
dc.contributor.author | Choi, Sang Zin | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-28T22:44:01Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14171 | - |
dc.description.abstract | A phytochemical investigation on the essential oil of Thuja orientalis resulted in the isolation and identification of three new sesquiterpenes, 3-methoxy-4-epoxythujopsane (1), (3,15)-4-epoxythujopsene (2), and (3,4)-thujopsen-2,15-diol (3), together with eight known sesquiterpenoids (4-11). The structures of these new compounds were elucidated based on spectroscopic data analyses including extensive 2D-NMR data and HR-ESIMS. The full assignments of H-1 and C-13 NMR chemical shifts for thujopsadiene (4) were obtained by 2D-NMR for the first time. All compounds (1-11) showed antiproliferative activities against the SK-OV-3 and SK-MEL-2 cell lines with IC50 values of 5.85-28.64 mu M. In addition, compounds 1, 3, 4, 7, 8, and 9 significantly inhibited nitric oxide production in lipopolysaccharide-activated BV-2 cells with IC50 values of 3.93-17.85 mu M without cell toxicity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.relation.isPartOf | PLANTA MEDICA | - |
dc.subject | THUJOPSENE | - |
dc.title | Bioactive Sesquiterpenes from the Essential Oil of Thuja orientalis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000327472000014 | - |
dc.identifier.doi | 10.1055/s-0033-1350952 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.79, no.17, pp.1680 - 1684 | - |
dc.identifier.scopusid | 2-s2.0-84889601536 | - |
dc.citation.endPage | 1684 | - |
dc.citation.startPage | 1680 | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 79 | - |
dc.citation.number | 17 | - |
dc.contributor.affiliatedAuthor | Moon, Eunjung | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Thuja orientalis | - |
dc.subject.keywordAuthor | Cupressaceae | - |
dc.subject.keywordAuthor | sesquiterpene | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordPlus | THUJOPSENE | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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