New synthetic aliphatic sulfonamido-quaternary ammonium salts as anticancer chemotherapeutic agents
DC Field | Value | Language |
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dc.contributor.author | Song, Doona | - |
dc.contributor.author | Yang, Jee Sun | - |
dc.contributor.author | Oh, Changmok | - |
dc.contributor.author | Cui, Shuolin | - |
dc.contributor.author | Kim, Bo-Kyung | - |
dc.contributor.author | Won, Misun | - |
dc.contributor.author | Lee, Jang-ik | - |
dc.contributor.author | Kim, Hwan Mook | - |
dc.contributor.author | Han, Gyoonhee | - |
dc.date.available | 2020-02-28T22:44:36Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14190 | - |
dc.description.abstract | RhoB is expressed during tumor cell proliferation, survival, invasion, and metastasis. In malignant progression, the expression levels of RhoB are commonly attenuated. RhoB is known to be linked to the regulation of the PI3K/Akt survival pathways. Based on aliphatic amido-quaternary ammonium salts that induce apoptosis via up-regulation of RhoB, we synthesized novel aliphatic sulfonamido-quaternary ammonium salts. These new synthetic compounds were evaluated for their biological activities using an in vitro RhoB promoter assay in HeLa cells, and in a growth inhibition assay using human cancer cell lines including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. Compound 5b (ethyl-dimethyl-{3-[methyl-(tetradecane-1-sulfonyl)-amino]-propyl}-ammonium; iodide) was the most promising anticancer agent in the series, based upon the potency of growth inhibition and RhoB promotion. These new aliphatic sulfonamido-quaternary ammonium salts could be a valuable series for development of new anticancer chemotherapeutic agents. (C) 2013 Elsevier Masson SAS. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.subject | RHOB EXPRESSION | - |
dc.subject | BIOLOGICAL EVALUATION | - |
dc.subject | LUNG-CANCER | - |
dc.subject | CELLS | - |
dc.subject | SUPPRESSION | - |
dc.subject | CARCINOMA | - |
dc.subject | APOPTOSIS | - |
dc.subject | PATHWAYS | - |
dc.subject | INVASION | - |
dc.subject | JNK | - |
dc.title | New synthetic aliphatic sulfonamido-quaternary ammonium salts as anticancer chemotherapeutic agents | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000330603900063 | - |
dc.identifier.doi | 10.1016/j.ejmech.2013.09.022 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.69, pp.670 - 677 | - |
dc.identifier.scopusid | 2-s2.0-84884787413 | - |
dc.citation.endPage | 677 | - |
dc.citation.startPage | 670 | - |
dc.citation.title | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.volume | 69 | - |
dc.contributor.affiliatedAuthor | Kim, Hwan Mook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Aliphatic sulfonamido-quaternary ammonium salts | - |
dc.subject.keywordAuthor | Anticancer chemotherapeutic agents | - |
dc.subject.keywordAuthor | Open-ring moiety of quaternary ammonium salts | - |
dc.subject.keywordAuthor | RhoB | - |
dc.subject.keywordAuthor | Perifosine | - |
dc.subject.keywordAuthor | NSC126188 | - |
dc.subject.keywordPlus | RHOB EXPRESSION | - |
dc.subject.keywordPlus | BIOLOGICAL EVALUATION | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | JNK | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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