Optimization of self-microemulsifying drug delivery system for telmisartan using Box-Behnken design and desirability function
DC Field | Value | Language |
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dc.contributor.author | Cho, Hyuk Jun | - |
dc.contributor.author | Lee, Dong Won | - |
dc.contributor.author | Marasini, Nirmal | - |
dc.contributor.author | Poudel, Bijay Kumar | - |
dc.contributor.author | Kim, Jeong Hwan | - |
dc.contributor.author | Ramasamy, Thiruganesh | - |
dc.contributor.author | Yoo, Bong Kyu | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.date.available | 2020-02-28T22:45:56Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 0022-3573 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14256 | - |
dc.description.abstract | Objectives To develop and optimize the novel self-microemulsifying drug delivery system (SMEDDS) formulation for enhanced water solubility and bioavailability of telmisartan (TMS) using the Box-Behnken design (BBD) and desirability function. Method TMS-SMEDDS formulation consisted of the mixture of oil (Peceol), surfactant (Labrasol), co-surfactant (Transcutol), TMS and triethanolamine. A three-level BBD was applied to explore the main effect, interaction effect and quadratic effect of three independent variables, including the amount of Peceol (X-1), Labrasol (X-2) and Transcutol (X-3). Determined conditions were 20 < X-1 < 40, 50 < X-2 < 80 and 5 < X-3 < 30. The response variables were droplet size (Y-1), polydispersity index (Y-2) and dissolution percentage of TMS after 15 min (Y-3). Key findings The optimized conditions were 28.93, 80 and 28.08 (mg) for X-1, X-2 and X-3, respectively, and the response variables were predicted to be 159.8 nm, 0.241 and 85.8% for Y-1, Y-2 and Y-3, respectively. The actual values from the optimized formulation showed good agreement with predicted values. The optimized TMS-SMEDDS formulation showed faster drug dissolution rate and higher bioavailability than TMS powder. Conclusions Our results suggest that response surface methodology using BBD and desirability function is a promising approach to understand the effect of SMEDDS variables and to optimize the formulation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | JOURNAL OF PHARMACY AND PHARMACOLOGY | - |
dc.subject | II RECEPTOR ANTAGONISTS | - |
dc.subject | SOLID DISPERSIONS | - |
dc.subject | EXCIPIENTS | - |
dc.subject | SMEDDS | - |
dc.title | Optimization of self-microemulsifying drug delivery system for telmisartan using Box-Behnken design and desirability function | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000324017600002 | - |
dc.identifier.doi | 10.1111/jphp.12115 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACY AND PHARMACOLOGY, v.65, no.10, pp.1440 - 1450 | - |
dc.identifier.scopusid | 2-s2.0-84883740113 | - |
dc.citation.endPage | 1450 | - |
dc.citation.startPage | 1440 | - |
dc.citation.title | JOURNAL OF PHARMACY AND PHARMACOLOGY | - |
dc.citation.volume | 65 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Yoo, Bong Kyu | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | bioavailability | - |
dc.subject.keywordAuthor | Box-Behnken design | - |
dc.subject.keywordAuthor | optimization | - |
dc.subject.keywordAuthor | self-microemulsifying drug delivery system | - |
dc.subject.keywordAuthor | telmisartan | - |
dc.subject.keywordPlus | II RECEPTOR ANTAGONISTS | - |
dc.subject.keywordPlus | SOLID DISPERSIONS | - |
dc.subject.keywordPlus | EXCIPIENTS | - |
dc.subject.keywordPlus | SMEDDS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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