Metabolic actions of Rho-kinase in periphery and brain
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Huang, Hu | - |
dc.contributor.author | Lee, Dae-Ho | - |
dc.contributor.author | Zabolotny, Janice M. | - |
dc.contributor.author | Kim, Young-Bum | - |
dc.date.available | 2020-02-28T22:46:06Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 1043-2760 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14266 | - |
dc.description.abstract | Obesity has increased at an alarming rate in recent years and is now a worldwide public health problem. Elucidating the mechanisms behind the metabolic dysfunctions associated with obesity is of high priority. The metabolic function of Rho-kinase (Rho-associated coiled-coil-containing kinase; ROCK) has been the subject of a great deal of investigation in metabolic-related diseases. It appears that inhibition of ROCK activity is beneficial for the treatment of a wide range of cardiovascular-related diseases. However, recent studies with genetic models of ROCK demonstrate that ROCK plays a positive role in insulin and leptin signaling. Here we discuss the newly identified functions of ROCK in regulating glucose and energy metabolism, with particular emphasis on metabolic actions of insulin and leptin. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE LONDON | - |
dc.relation.isPartOf | TRENDS IN ENDOCRINOLOGY AND METABOLISM | - |
dc.subject | INSULIN-RECEPTOR SUBSTRATE-1 | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | SIGNAL TRANSDUCER | - |
dc.subject | SMOOTH-MUSCLE | - |
dc.subject | POMC NEURONS | - |
dc.subject | SERINE/THREONINE KINASE | - |
dc.subject | PUTATIVE TARGET | - |
dc.subject | DOUBLE-BLIND | - |
dc.subject | ROK-ALPHA | - |
dc.subject | LEPTIN | - |
dc.title | Metabolic actions of Rho-kinase in periphery and brain | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000325588400004 | - |
dc.identifier.doi | 10.1016/j.tem.2013.06.003 | - |
dc.identifier.bibliographicCitation | TRENDS IN ENDOCRINOLOGY AND METABOLISM, v.24, no.10, pp.506 - 514 | - |
dc.identifier.scopusid | 2-s2.0-84884412641 | - |
dc.citation.endPage | 514 | - |
dc.citation.startPage | 506 | - |
dc.citation.title | TRENDS IN ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.volume | 24 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Kim, Young-Bum | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Rho-kinase | - |
dc.subject.keywordAuthor | glucose metabolism | - |
dc.subject.keywordAuthor | insulin action | - |
dc.subject.keywordAuthor | energy homeostasis | - |
dc.subject.keywordAuthor | leptin action | - |
dc.subject.keywordPlus | INSULIN-RECEPTOR SUBSTRATE-1 | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | SIGNAL TRANSDUCER | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE | - |
dc.subject.keywordPlus | POMC NEURONS | - |
dc.subject.keywordPlus | SERINE/THREONINE KINASE | - |
dc.subject.keywordPlus | PUTATIVE TARGET | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | ROK-ALPHA | - |
dc.subject.keywordPlus | LEPTIN | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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