Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo
DC Field | Value | Language |
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dc.contributor.author | Lee, Ik-Soo | - |
dc.contributor.author | Yu, Song Yi | - |
dc.contributor.author | Jung, Seung-Hyun | - |
dc.contributor.author | Lee, Yu-Ri | - |
dc.contributor.author | Lee, Yun Mi | - |
dc.contributor.author | Kim, Joo-Hwan | - |
dc.contributor.author | Sun, Hang | - |
dc.contributor.author | Kim, Jin Sook | - |
dc.date.available | 2020-02-28T22:46:25Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14280 | - |
dc.description.abstract | Three new A-type proanthocyanidins (1-3), ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin 3'-O-beta-D-glycopyranoside (1), ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin (2), and ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8) -ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin (3), and three known compounds (4-6) were isolated from the whole plant of Spenceria ramalana. The structures of the new proanthocyanidins were established by spectroscopic and chemical studies. The inhibitory effects of compounds 1-6 on the formation of advanced glycation end products were examined in vitro. Compounds 3 and 6 showed the strongest inhibition, with IC50 values of 17.4 +/- 0.5 and 14.1 +/- 1.6 mu M, respectively. The effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in larval zebrafish were also investigated. Compound 3 reduced the dilation of HG-induced hyaloid-retinal vessels most effectively. This compound reduced the diameters of HG-induced hyaloid-retinal vessels by about 157.7% and 164.1% at 10 and 20 mu M, respectively, versus the HG-treated control group. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.subject | A-TYPE PROANTHOCYANIDINS | - |
dc.subject | END-PRODUCTS AGES | - |
dc.subject | PROTEIN GLYCATION | - |
dc.subject | FLAVONOIDS | - |
dc.subject | TANNINS | - |
dc.title | Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000326319700009 | - |
dc.identifier.doi | 10.1021/np400442b | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.76, no.10, pp.1881 - 1888 | - |
dc.identifier.scopusid | 2-s2.0-84886842622 | - |
dc.citation.endPage | 1888 | - |
dc.citation.startPage | 1881 | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 76 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Kim, Joo-Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | A-TYPE PROANTHOCYANIDINS | - |
dc.subject.keywordPlus | END-PRODUCTS AGES | - |
dc.subject.keywordPlus | PROTEIN GLYCATION | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | TANNINS | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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