The extract of Tamarindus indica L. suppresses IKK beta activity and NF-kappa B-dependent lymphoblastoid cell line survival
DC Field | Value | Language |
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dc.contributor.author | Lim, Sue Yeon | - |
dc.contributor.author | Song, Yoon-Jae | - |
dc.date.available | 2020-02-28T22:46:46Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 1738-642X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14293 | - |
dc.description.abstract | The NF-kappa B family of transcription factors is a critical regulator for the cell survival by inducing the expression of anti-apoptotic genes. In this study, we found that a seventy percent ethanol extract of Tamarindus indica L. (TIE) strongly inhibits both IL-1 beta- and lipopolysaccharide (LPS)-induced IKK beta and NF-kappa B activation without affecting the activity of IL-1 receptor associated kinase 1 (IRAK1), which functions upstream of IKK beta. In addition, FIE had no effect on the LPS-induced c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) activation. Furthermore, TIE clearly reduced the viability of NF-kappa B-dependent lymphoblastoid cell line (LCL) without adversely affecting the viability of NF-kappa B-independent HeLa cells. Thus, TIE targets IKK beta to inhibit NF-kappa B activation and LCL viability. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT | - |
dc.relation.isPartOf | MOLECULAR & CELLULAR TOXICOLOGY | - |
dc.title | The extract of Tamarindus indica L. suppresses IKK beta activity and NF-kappa B-dependent lymphoblastoid cell line survival | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000325123700006 | - |
dc.identifier.doi | 10.1007/s13273-013-0031-2 | - |
dc.identifier.bibliographicCitation | MOLECULAR & CELLULAR TOXICOLOGY, v.9, no.3, pp.243 - 248 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84885417698 | - |
dc.citation.endPage | 248 | - |
dc.citation.startPage | 243 | - |
dc.citation.title | MOLECULAR & CELLULAR TOXICOLOGY | - |
dc.citation.volume | 9 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Lim, Sue Yeon | - |
dc.contributor.affiliatedAuthor | Song, Yoon-Jae | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | Tamarindus indica L. cell death | - |
dc.subject.keywordPlus | HUMAN CYTOMEGALOVIRUS | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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