Association of the Catechol-o-Methyltransferase Gene Polymorphisms with Korean Autism Spectrum Disorders
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Hee Jeong | - |
dc.contributor.author | Cho, In Hee | - |
dc.contributor.author | Park, Mira | - |
dc.contributor.author | Yang, So Young | - |
dc.contributor.author | Kim, Soon Ae | - |
dc.date.available | 2020-02-28T22:47:15Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14317 | - |
dc.description.abstract | This study evaluated the family-based genetic association between autism spectrum disorders (ASDs) and 5 single-nucleotide polymorphisms (SNPs) in the catechol-o-methyltransferase gene (COMT), which was found among 151 Korean ASDs family trios (dominant model Z = 2.598, P = 0.009, P-FDR = 0.045). We found a statistically significant allele transmission or association in terms of the rs6269 SNP in the ASDs trios. Moreover, in the haplotype analysis, the haplotypes with rs6269 demonstrated significant evidence of an association with ASDs (additive model rs6269-rs4818-rs4680-rs769224 haplotype P = 0.004, P-FDR = 0.040). Thus, an association may exist between the variants of the COMT gene and the occurrence of ASDs in Koreans. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.subject | PROMOTER REGION | - |
dc.subject | ENZYME-ACTIVITY | - |
dc.subject | COMT | - |
dc.subject | SCHIZOPHRENIA | - |
dc.subject | PHENOTYPES | - |
dc.subject | BRAIN | - |
dc.title | Association of the Catechol-o-Methyltransferase Gene Polymorphisms with Korean Autism Spectrum Disorders | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000324547000024 | - |
dc.identifier.doi | 10.3346/jkms.2013.28.9.1403 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.28, no.9, pp.1403 - 1406 | - |
dc.identifier.kciid | ART001802036 | - |
dc.identifier.scopusid | 2-s2.0-84884393720 | - |
dc.citation.endPage | 1406 | - |
dc.citation.startPage | 1403 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 28 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Cho, In Hee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Autism Spectrum Disorders (ASD) | - |
dc.subject.keywordAuthor | Polymorphisms, Single Nucleotide (SNPs) | - |
dc.subject.keywordAuthor | Catechol-O-Methyltransferase Gene (COMT) | - |
dc.subject.keywordAuthor | Family-Based Association Study | - |
dc.subject.keywordPlus | PROMOTER REGION | - |
dc.subject.keywordPlus | ENZYME-ACTIVITY | - |
dc.subject.keywordPlus | COMT | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordPlus | PHENOTYPES | - |
dc.subject.keywordPlus | BRAIN | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.