6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation
DC Field | Value | Language |
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dc.contributor.author | Park, Gunhyuk | - |
dc.contributor.author | Kim, Hyo Geun | - |
dc.contributor.author | Ju, Mi Sun | - |
dc.contributor.author | Ha, Sang Keun | - |
dc.contributor.author | Park, Yongkon | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Oh, Myung Sook | - |
dc.date.available | 2020-02-28T23:42:09Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 1671-4083 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14346 | - |
dc.description.abstract | Aim: 6-Shogaol [1-(4-hydroxy-methoxyphenyl)-4-decen-one], a pungent compound isolated from ginger, has shown various neurobiological and anti-inflammatory effects. The aim of this study was to examine the effects of 6-shogaol on neuroinflammatory-induced damage of dopaminergic (DA) neurons in Parkinson's disease (PD) models. Methods: Cultured rat mesencephalic cells were treated with 6-shogaol (0.001 and 0.01 mu mol/L) for 1 h, then with MPP+ (10 mu mol/L) for another 23 h. The levels of TNF-alpha and NO in medium were analyzed spectrophotometrically. C57/BL mice were administered 6-shogaol (10 mg.kg(-1).d(-1), po) for 3 d, and then MPTP (30 mg/kg, ip) for 5 d. Seven days after the last MPTP injection, behavioral testings were performed. The levels of tyrosine hydroxylase (TH) and macrophage antigen (MAC)-1 were determined with immunohistochemistry. The expression of iNOS and COX-2 was measured using RT PCR. Results: In MPP+-treated rat mesencephalic cultures, 6-shogaol significantly increased the number of TH-IR neurons and suppressed TNF-alpha and NO levels. In C57/BL mice, treatment with 6-shogaol reversed MPTP-induced changes in motor coordination and bradykinesia. Furthermore, 6-shogaol reversed MPTP-induced reductions in TH-positive cell number in the substantia nigra pars compacta (SNpc) and TH-IR fiber intensity in stratum (ST). Moreover, 6-shogaol significantly inhibited the MPTP-induced microglial activation and increases in the levels of TNF-alpha, NO, iNOS, and COX-2 in both SNpc and ST. Conclusion: 6-Shogaol exerts neuroprotective effects on DA neurons in in vitro and in vivo PD models. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | ACTA PHARMACOLOGICA SINICA | - |
dc.subject | KAPPA-B ACTIVATION | - |
dc.subject | INFLAMMATION | - |
dc.subject | SUPPRESSION | - |
dc.subject | MECHANISMS | - |
dc.subject | EXPRESSION | - |
dc.subject | MICROGLIA | - |
dc.subject | PRODUCT | - |
dc.subject | MPTP | - |
dc.title | 6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000324170400002 | - |
dc.identifier.doi | 10.1038/aps.2013.57 | - |
dc.identifier.bibliographicCitation | ACTA PHARMACOLOGICA SINICA, v.34, no.9, pp.1131 - 1139 | - |
dc.identifier.scopusid | 2-s2.0-84883734377 | - |
dc.citation.endPage | 1139 | - |
dc.citation.startPage | 1131 | - |
dc.citation.title | ACTA PHARMACOLOGICA SINICA | - |
dc.citation.volume | 34 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 6-shogaol | - |
dc.subject.keywordAuthor | ginger | - |
dc.subject.keywordAuthor | dopaminergic neurons | - |
dc.subject.keywordAuthor | substantia nigra | - |
dc.subject.keywordAuthor | stratum | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | neuroinflammation | - |
dc.subject.keywordAuthor | microglia | - |
dc.subject.keywordAuthor | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MICROGLIA | - |
dc.subject.keywordPlus | PRODUCT | - |
dc.subject.keywordPlus | MPTP | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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