Anticancer Potency and Multidrug-Resistant Studies of Self-Assembled Arene-Ruthenium Metallarectangles
DC Field | Value | Language |
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dc.contributor.author | Dubey, Abhishek | - |
dc.contributor.author | Min, Jin Wook | - |
dc.contributor.author | Koo, Hyun Jung | - |
dc.contributor.author | Kim, Hyunuk | - |
dc.contributor.author | Cook, Timothy R. | - |
dc.contributor.author | Kang, Se Chan | - |
dc.contributor.author | Stang, Peter J. | - |
dc.contributor.author | Chi, Ki-Whan | - |
dc.date.available | 2020-02-28T23:42:48Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-08-26 | - |
dc.identifier.issn | 0947-6539 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14371 | - |
dc.description.abstract | A suite of three tetraruthenium metallacycles have been obtained from [2+2] self-assemblies between N,N'-Di-(4-pyridyl)-1,4,5,8-naphthalenetetracarbo-xydiimide (4) and one of the three dinuclear arene ruthenium clips, (eta(6)-p-iPrC(6)H(4)Me)(2)Ru-2(OO boolean AND OO)][OTf](2) (OO boolean AND OO=oxalate 1, 2,5-dioxydo-1,4-benzoquinonato (dobq) 2, 5,8-dihydroxy-1,4-naphthaquinonato (donq) 3; OTf=triflate). All complexes were isolated in good yield (>85%) as triflate salts and were fully characterized by using (HNMR)-H-1 and UV/Vis spectroscopies, and high-resolution electrospray mass spectrometry. A single crystal of the metallarectangle 5 was suitable for X-ray diffraction structural characterization. The biological activities of the metallacycles were determined by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assays, establishing their in vitro anticancer properties. Our results show that for the AGC (gastric cancer) cell lines, the cytotoxicity of (donq)-containing SCC 7 exceeds that of cisplatin, which was used as a control. For HCT15 (colon cancer) cell lines, the cytotoxicity is comparable to both cisplatin and doxorubicin. An in vivo hollow fiber model was used to show growth-inhibitory activity against HCT15 and image-based cytometry experiments indicated that 7 induced apoptosis as the mode of cell death. Complex 7 also showed significant antitumor activity for multidrug-resistant HCT15/CLO2 cell lines, for which doxorubicin was ineffective. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | CHEMISTRY-A EUROPEAN JOURNAL | - |
dc.subject | MOLECULAR-RECTANGLES | - |
dc.subject | P-GLYCOPROTEIN | - |
dc.subject | DRUG-RESISTANCE | - |
dc.subject | CELL-LINES | - |
dc.subject | CANCER | - |
dc.subject | COMPLEXES | - |
dc.subject | DESIGN | - |
dc.subject | ESTABLISHMENT | - |
dc.subject | IMIDAZOLE | - |
dc.subject | CHEMISTRY | - |
dc.title | Anticancer Potency and Multidrug-Resistant Studies of Self-Assembled Arene-Ruthenium Metallarectangles | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000323196500028 | - |
dc.identifier.doi | 10.1002/chem.201300870 | - |
dc.identifier.bibliographicCitation | CHEMISTRY-A EUROPEAN JOURNAL, v.19, no.35, pp.11622 - 11628 | - |
dc.identifier.scopusid | 2-s2.0-84882820001 | - |
dc.citation.endPage | 11628 | - |
dc.citation.startPage | 11622 | - |
dc.citation.title | CHEMISTRY-A EUROPEAN JOURNAL | - |
dc.citation.volume | 19 | - |
dc.citation.number | 35 | - |
dc.contributor.affiliatedAuthor | Koo, Hyun Jung | - |
dc.contributor.affiliatedAuthor | Kang, Se Chan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | antitumor agents | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordAuthor | metallarectangles | - |
dc.subject.keywordAuthor | multidrug resistance | - |
dc.subject.keywordAuthor | ruthenium | - |
dc.subject.keywordAuthor | self-assembly | - |
dc.subject.keywordPlus | MOLECULAR-RECTANGLES | - |
dc.subject.keywordPlus | P-GLYCOPROTEIN | - |
dc.subject.keywordPlus | DRUG-RESISTANCE | - |
dc.subject.keywordPlus | CELL-LINES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | ESTABLISHMENT | - |
dc.subject.keywordPlus | IMIDAZOLE | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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