Polyphenols from the bark of Rhus verniciflua and their biological evaluation on antitumor and anti-inflammatory activities
DC Field | Value | Language |
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dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Moon, Eunjung | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-28T23:43:02Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 0031-9422 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14380 | - |
dc.description.abstract | Bioassay-guided fractionation and chemical investigation of the extract of Rhus verniciflua bark resulted in the identification of six polyphenols, rhusopolyphenols A-F (1-6), together with four known compounds including (2R,3S,10S)-7,8,9,13-tetrahydroxy-2-(3,4-dihydroxyphenyl)-2,3-trans-3,4-cis-2,3,10-trihydrobenzopyrano[3,4-c]-2-benzopyran-1-one (7), peapolyphenol C (8), cilicione-b (9) and (alpha R)-alpha,3,4,2',4'-pentahydroxydihydrochalcone (10). The structures of these polyphenols were elucidated by spectroscopic analysis, including 1D and 2D NMR, and HR-ESIMS, and their absolute configurations were further confirmed by a combination of chemical methods and CD data analysis. All isolates were evaluated for their antiproliferative activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15), and compounds 4-6, 9 and 10 showed antiproliferative activity against the tested cells, with IC50 values of 3.31-18.51 mu M. On the basis of the expanded understanding that inflammation is a crucial cause of tumor progression, the anti-inflammatory activities of these compounds were determined by measuring nitric oxide (NO) levels in the medium of murine microglia BV-2 cells. Compounds 5 and 10 significantly inhibited NO production in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells with IC50 values of 28.90 and 12.70 mu M, respectively. (c) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | PHYTOCHEMISTRY | - |
dc.subject | SESQUITERPENE LACTONES | - |
dc.subject | FLAVONOIDS | - |
dc.subject | CELLS | - |
dc.subject | CANCER | - |
dc.subject | STOKES | - |
dc.subject | CARCINOMA | - |
dc.subject | APOPTOSIS | - |
dc.subject | EXTRACT | - |
dc.title | Polyphenols from the bark of Rhus verniciflua and their biological evaluation on antitumor and anti-inflammatory activities | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000321596000011 | - |
dc.identifier.doi | 10.1016/j.phytochem.2013.05.005 | - |
dc.identifier.bibliographicCitation | PHYTOCHEMISTRY, v.92, pp.113 - 121 | - |
dc.identifier.scopusid | 2-s2.0-84884909879 | - |
dc.citation.endPage | 121 | - |
dc.citation.startPage | 113 | - |
dc.citation.title | PHYTOCHEMISTRY | - |
dc.citation.volume | 92 | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Rhus verniciflua | - |
dc.subject.keywordAuthor | Anacardiaceae | - |
dc.subject.keywordAuthor | Polyphenols | - |
dc.subject.keywordAuthor | Rhusopolyphenols | - |
dc.subject.keywordAuthor | Antitumor | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordPlus | SESQUITERPENE LACTONES | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | STOKES | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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