Role of Interleukin 28B-related Gene Polymorphisms in Chronic Hepatitis C and the Response to Antiviral Therapy in Koreans
- Authors
- Jung, Young Kul; Kim, Ji Hoon; Ahn, Sung-Min; Yang, Jae Won; Park, Sang Jin; Kim, Jong Woo; Yeon, Jong Eun; Kwon, Oh Sang; Kim, Yun Soo; Choi, Duck Joo; Kim, Ju Hyun; Byun, Kwan Soo
- Issue Date
- Aug-2013
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- IL28B; gene polymorphism; hepatitis C virus; antiviral therapy; Korean
- Citation
- JOURNAL OF CLINICAL GASTROENTEROLOGY, v.47, no.7, pp.644 - 650
- Journal Title
- JOURNAL OF CLINICAL GASTROENTEROLOGY
- Volume
- 47
- Number
- 7
- Start Page
- 644
- End Page
- 650
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14388
- DOI
- 10.1097/MCG.0b013e3182896abf
- ISSN
- 0192-0790
- Abstract
- Background: Genetic variations in interleukin 28B (IL28B) have been strongly associated with a sustained virological response (SVR) in European and African-American patients. Genetic variation of IL28B was investigated in healthy controls and chronic hepatitis C (CHC) patients, and the treatment response in the CHC patients was analyzed according to IL28B polymorphism in the Korean population. Methods: IL28B polymorphisms (rs12979860 and rs8099917) were studied in 200 healthy controls and in 167 CHC patients who were treated with peginterferon- and ribavirin. Results: The prevalence of rs12979860 in healthy controls is as follows: the CC-genotype was 88.5%, the CT-genotype was 11.5%, and the TT-genotype was not found. The prevalence of rs8099917 in healthy controls is as follows: the TT-genotype was 89.5%, the TG-genotype was 10.5%, and the GG-genotype was not found. The CC-genotype of rs12979860 and the TT-genotype of rs8099917 were found to be closely related (linkage disequilibrium; D=1.0, (2)=0.9082). In 106 CHC patients treated with peginterferon and ribavirin, the SVR was 67.2% (n=58) for 1b, 91.6% (n=47) for 2a. In hepatitis C virus (HCV) genotype 1b with respect to rs12979860, the SVR in CC-genotype was 72.9% and that in CT-genotype was 40.0%. On investigating predictive factors for SVR, pretreatment low-HCV RNA levels, HCV genotype non-1, early virological response, and also the IL28B CC-genotype for rs12979860 were good indicators of an SVR. Conclusions: In Korea, genetic variation of IL28B is different from that in western countries in view of high prevalence of rs12979860 CC-genotype. It seems likely that a high SVR in Korean patients with genotype 1 CHC patients is due to the genetic polymorphism in IL28B.
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