The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean
DC Field | Value | Language |
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dc.contributor.author | Kim, Ju Seung | - |
dc.contributor.author | Ahn, Sung-Min | - |
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Kwon, Oh Sang | - |
dc.contributor.author | Kim, Yun Soo | - |
dc.contributor.author | Choi, Duck Joo | - |
dc.contributor.author | Kim, Ju Hyun | - |
dc.date.available | 2020-02-28T23:43:33Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14405 | - |
dc.description.abstract | Two variants of the inosine triphosphatase (ITPA: rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin. We investigated the clinical significance of ITPA variants in Korean patients treated with pegylated interferon (PEG-IFN) plus ribavirin. Of the 133 patients, 108 were CC and 25 were non-CC at rs1127354 (groups A and B, respectively). On the other hand, at rs7270101 all 133 were AA. The mean values of Hemoglobin (Hgb) after 4, 8, and 12 weeks of treatment in groups A and B were 12.2 and 14.0, 11.8 and 13.2, and 11.5 and 12.9, respectively (P = 0.001, 0.036, 0.036). Sustained virologic response (SVR) was achieved in 67.8% (40/59) of genotype 1 patients and in 75% (27/36) of non-genotype 1 patients. Regarding ITPA variants, SVR was achieved by 66% and 80% of genotype 1 (P = 0.282), and by 78% and 71% (P = 0.726) of non-genotype 1. SVR was not significantly different in groups A and B. In conclusion, non-CC at rs1127354 without involvement of rs7270101 is strongly associated with protection from ribavirin-induced anemia, however, ITPA genotype is not associated with SVR. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.subject | RIBAVIRIN DOSE REDUCTION | - |
dc.subject | VIRUS-INFECTION | - |
dc.subject | PEGINTERFERON ALPHA-2A | - |
dc.subject | COMBINATION THERAPY | - |
dc.subject | HEMOLYTIC-ANEMIA | - |
dc.subject | PLUS RIBAVIRIN | - |
dc.subject | INTERFERON-ALPHA-2B | - |
dc.subject | PREVALENCE | - |
dc.subject | PROTECT | - |
dc.subject | TRIAL | - |
dc.title | The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000324502100017 | - |
dc.identifier.doi | 10.3346/jkms.2013.28.8.1213 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.28, no.8, pp.1213 - 1219 | - |
dc.identifier.kciid | ART001792755 | - |
dc.identifier.scopusid | 2-s2.0-84884364955 | - |
dc.citation.endPage | 1219 | - |
dc.citation.startPage | 1213 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 28 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Kim, Ju Seung | - |
dc.contributor.affiliatedAuthor | Ahn, Sung-Min | - |
dc.contributor.affiliatedAuthor | Jung, Young Kul | - |
dc.contributor.affiliatedAuthor | Kwon, Oh Sang | - |
dc.contributor.affiliatedAuthor | Kim, Yun Soo | - |
dc.contributor.affiliatedAuthor | Choi, Duck Joo | - |
dc.contributor.affiliatedAuthor | Kim, Ju Hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Hepatitis C, Chronic | - |
dc.subject.keywordAuthor | Ribavirin | - |
dc.subject.keywordAuthor | Anemia | - |
dc.subject.keywordAuthor | ITPA | - |
dc.subject.keywordAuthor | IL28B | - |
dc.subject.keywordPlus | RIBAVIRIN DOSE REDUCTION | - |
dc.subject.keywordPlus | VIRUS-INFECTION | - |
dc.subject.keywordPlus | PEGINTERFERON ALPHA-2A | - |
dc.subject.keywordPlus | COMBINATION THERAPY | - |
dc.subject.keywordPlus | HEMOLYTIC-ANEMIA | - |
dc.subject.keywordPlus | PLUS RIBAVIRIN | - |
dc.subject.keywordPlus | INTERFERON-ALPHA-2B | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | PROTECT | - |
dc.subject.keywordPlus | TRIAL | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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