The protective effect of Prunella vulgaris ethanol extract against vascular inflammation in TNF-alpha-stimulated human aortic smooth muscle cells
DC Field | Value | Language |
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dc.contributor.author | Park, Sun Haeng | - |
dc.contributor.author | Koo, Hyun Jung | - |
dc.contributor.author | Sung, Yoon Young | - |
dc.contributor.author | Kim, Ho Kyoung | - |
dc.date.available | 2020-02-28T23:44:01Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-07-31 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14417 | - |
dc.description.abstract | Atherosclerosis, which manifests as acute coronary syndrome, stroke, and peripheral arterial diseases, is a chronic inflammatory disease of the arterial wall. Prunella vulgaris, a perennial herb with a worldwide distribution, has been used as a traditional medicine in inflammatory disease. Here, we investigated the effects of P. vulgaris ethanol extract on TNF-alpha-induced inflammatory responses in human aortic smooth muscle cells (HASMCs). We found that P. vulgaris ethanol extract inhibited adhesion of monocyte/macrophage-like THP-1 cells to activated HASMCs. It also decreased expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, E-selectin and ROS, No production in TNF-alpha-induced HASMCs and reduced NF-kB activation. Furthermore, P. vulgaris extract suppressed TNF-alpha-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). These results demonstrate that P. vulgaris possesses anti-inflammatory properties and can regulate TNF-alpha-induced expression of adhesion molecules by inhibiting the p38 MAPK/ERK signaling pathway. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | INTERCELLULAR-ADHESION MOLECULE-1 | - |
dc.subject | HUMAN ATHEROSCLEROSIS | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | URSOLIC ACID | - |
dc.subject | E-SELECTIN | - |
dc.subject | EXPRESSION | - |
dc.subject | ICAM-1 | - |
dc.subject | ACTIVATION | - |
dc.subject | PATHOGENESIS | - |
dc.title | The protective effect of Prunella vulgaris ethanol extract against vascular inflammation in TNF-alpha-stimulated human aortic smooth muscle cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000324921000004 | - |
dc.identifier.doi | 10.5483/BMBRep.2013.46.7.214 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.46, no.7, pp.352 - 357 | - |
dc.identifier.kciid | ART001790524 | - |
dc.identifier.scopusid | 2-s2.0-84883807925 | - |
dc.citation.endPage | 357 | - |
dc.citation.startPage | 352 | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 46 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Koo, Hyun Jung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Adhesion molecules | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | Human aortic smooth muscle cells | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Prunella vulgaris | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | INTERCELLULAR-ADHESION MOLECULE-1 | - |
dc.subject.keywordPlus | HUMAN ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | URSOLIC ACID | - |
dc.subject.keywordPlus | E-SELECTIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ICAM-1 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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