Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica
DC Field | Value | Language |
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dc.contributor.author | Woo, Kyeong Wan | - |
dc.contributor.author | Moon, Eunjung | - |
dc.contributor.author | Kwon, Oh Wook | - |
dc.contributor.author | Lee, Sung Ok | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Choi, Sang Zin | - |
dc.contributor.author | Son, Mi Won | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-28T23:44:12Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-07-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14428 | - |
dc.description.abstract | In a continuing search for bioactive constituents from Dioscoreaceae medicinal plants, two new cyclic diarylheptanoids, diosniponol A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of Dioscorea nipponica. The structures of these new compounds were determined by spectroscopic analyses, including extensive two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and optical rotation. All isolated compounds 1-12 were evaluated for their effects on nitric oxide (NO) production in murine microglia cell line BV-2. Compounds 8 and 11 showed potent inhibitory activities on NO production (IC50 13.36 and 14.36 mu M, respectively) without cell toxicity in lipopolysaccharide-activated BV-2 cells. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.subject | NITRIC-OXIDE PRODUCTION | - |
dc.subject | AMOMUM-TSAO-KO | - |
dc.subject | ZINGIBER-OFFICINALE | - |
dc.subject | INHIBITORY-ACTIVITY | - |
dc.subject | BV2 MICROGLIA | - |
dc.subject | MAKINO | - |
dc.subject | STEMS | - |
dc.subject | CONSTITUENTS | - |
dc.subject | MACROPHAGES | - |
dc.subject | LEAVES | - |
dc.title | Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000320702900025 | - |
dc.identifier.doi | 10.1016/j.bmcl.2013.04.073 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.13, pp.3806 - 3809 | - |
dc.identifier.scopusid | 2-s2.0-84878862779 | - |
dc.citation.endPage | 3809 | - |
dc.citation.startPage | 3806 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 23 | - |
dc.citation.number | 13 | - |
dc.contributor.affiliatedAuthor | Moon, Eunjung | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Dioscorea nipponica | - |
dc.subject.keywordAuthor | Dioscoreaceae | - |
dc.subject.keywordAuthor | Diarylheptanoids | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | Anti-neuroinflammation | - |
dc.subject.keywordPlus | NITRIC-OXIDE PRODUCTION | - |
dc.subject.keywordPlus | AMOMUM-TSAO-KO | - |
dc.subject.keywordPlus | ZINGIBER-OFFICINALE | - |
dc.subject.keywordPlus | INHIBITORY-ACTIVITY | - |
dc.subject.keywordPlus | BV2 MICROGLIA | - |
dc.subject.keywordPlus | MAKINO | - |
dc.subject.keywordPlus | STEMS | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | LEAVES | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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