Anxiolytic effects of Julibroside C-1 isolated from Albizzia julibrissin in mice
DC Field | Value | Language |
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dc.contributor.author | Jung, Yang-Hee | - |
dc.contributor.author | Ha, Ri-Ra | - |
dc.contributor.author | Kwon, Seung-Hwan | - |
dc.contributor.author | Hong, Sa-Ik | - |
dc.contributor.author | Lee, Kun-Ho | - |
dc.contributor.author | Kim, Sun-Yeou | - |
dc.contributor.author | Lee, Seok-Yong | - |
dc.contributor.author | Jang, Choon-Gon | - |
dc.date.available | 2020-02-28T23:44:13Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-07-01 | - |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14429 | - |
dc.description.abstract | Julibroside C-1 is a saponin-containing compound isolated from Albizzia julibrissin Durazz. In this study, we investigated the putative anxiolytic effects ofJulibroside C-1 using the elevated plus maze (EPM) in mice. Julibroside C-1 at doses of 0.5 and 1 mg/kg significantly increased the time spent in the open arms and the number of entries into the open arms of the EPM compared to the control group. Moreover, the anxiolytic-like effects of Julibroside (0.5 mg/kg) were blocked by WAY-100635 (5-HT1A receptor antagonist), bicuculline (GABA(A) receptor antagonist), and flumazenil (antagonist of the GABAA receptor benzodiazepine site). However, Julibroside C-1 did not change locomotor activity or induce myorelaxant effects. We used quantitative receptor autoradiography to investigate the effects of Julibroside C-1 on alterations in mouse brain receptors. After acute treatment with Julibroside (0.5 mg/kg), [H-3]-8-0H-DPAT binding was significantly decreased in the CA1 region of the hippocampus and [H-3]-flunitrazepam binding was decreased remarkably in the cingulate cortex region. However, [H-3]-muscimol binding did not show a significant change in any brain region. Taken together, our findings suggest that Julibroside C1 shows anxiolytic-like effects, which might be mediated by the 5-HT1A and GABA(A)-benzodiazepine receptor systems. (C) 2013 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.subject | ELEVATED PLUS-MAZE | - |
dc.subject | RAT-BRAIN | - |
dc.subject | BENZODIAZEPINE-RECEPTOR | - |
dc.subject | 5-HYDROXYTRYPTAMINE(1A) RECEPTORS | - |
dc.subject | ANXIETY DISORDERS | - |
dc.subject | 5-HT1A RECEPTORS | - |
dc.subject | ANIMAL-MODELS | - |
dc.subject | INVOLVEMENT | - |
dc.subject | PHARMACOLOGY | - |
dc.subject | HIPPOCAMPUS | - |
dc.title | Anxiolytic effects of Julibroside C-1 isolated from Albizzia julibrissin in mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000320297400025 | - |
dc.identifier.doi | 10.1016/j.pnpbp.2013.02.012 | - |
dc.identifier.bibliographicCitation | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.44, pp.184 - 192 | - |
dc.identifier.scopusid | 2-s2.0-84876014473 | - |
dc.citation.endPage | 192 | - |
dc.citation.startPage | 184 | - |
dc.citation.title | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.citation.volume | 44 | - |
dc.contributor.affiliatedAuthor | Kim, Sun-Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 5-HT1A | - |
dc.subject.keywordAuthor | Anxiolytic effects | - |
dc.subject.keywordAuthor | Benzodiazepine | - |
dc.subject.keywordAuthor | GABA(A) | - |
dc.subject.keywordAuthor | Julibroside C-1 | - |
dc.subject.keywordPlus | ELEVATED PLUS-MAZE | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.subject.keywordPlus | BENZODIAZEPINE-RECEPTOR | - |
dc.subject.keywordPlus | 5-HYDROXYTRYPTAMINE(1A) RECEPTORS | - |
dc.subject.keywordPlus | ANXIETY DISORDERS | - |
dc.subject.keywordPlus | 5-HT1A RECEPTORS | - |
dc.subject.keywordPlus | ANIMAL-MODELS | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | PHARMACOLOGY | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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