Elaeagnus glabra f. oxyphylla Attenuates Scopolamine-Induced Learning and Memory Impairments in Mice by Improving Cholinergic Transmission via Activation of CREB/NGF Signaling
DC Field | Value | Language |
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dc.contributor.author | Sohn, Eunjin | - |
dc.contributor.author | Lim, Hye-Sun | - |
dc.contributor.author | Kim, Yu Jin | - |
dc.contributor.author | Kim, Bu-Yeo | - |
dc.contributor.author | Kim, Joo-Hwan | - |
dc.contributor.author | Jeong, Soo-Jin | - |
dc.date.available | 2020-02-27T03:40:49Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1445 | - |
dc.description.abstract | We aimed to investigate the therapeutic effects of an Elaeagnus glabra f. oxyphylla (EGFO) ethanol extract in mice with scopolamine-induced memory dysfunction. Fifty male mice were randomly divided into a normal control group, a scopolamine-treated group, a scopolamine and EGFO extract-treated group, and a scopolamine and tacrine-treated group. EGFO (50 or 100 mg/kg/day) was received for 21 days. Step-through passive avoidance and Y-maze tests were performed to examine the effects of treatment on learning and memory impairments. Acetylcholine (Ach) levels and acetylcholinesterase (AchE) activity were measured via an enzyme-linked immunosorbent assay (ELISA). Levels of choline acetyltransferase (ChAT), nerve growth factor (NGF), cAMP response element-binding protein (CREB), and apoptosis-related protein expression were determined via Western blot analysis. EGFO pretreatment significantly attenuated scopolamine-induced memory impairments, relative to findings observed in the scopolamine-treated group. Levels of cholinergic factors in the brain tissues were markedly attenuated in the scopolamine-treated group. EGFO treatment also attenuated neural apoptosis in scopolamine-treated mice by decreasing the expression of apoptosis-related proteins such as Bax, Bcl2, cleaved caspase-3, and TUNEL staining. These results suggest that EGFO improves memory and cognition in a mouse model of memory impairment by restoring cholinergic and anti-apoptotic activity, possibly via activation of CREB/NGF signaling. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | NUTRIENTS | - |
dc.title | Elaeagnus glabra f. oxyphylla Attenuates Scopolamine-Induced Learning and Memory Impairments in Mice by Improving Cholinergic Transmission via Activation of CREB/NGF Signaling | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000474936700011 | - |
dc.identifier.doi | 10.3390/nu11061205 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.11, no.6 | - |
dc.identifier.scopusid | 2-s2.0-85067296824 | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Kim, Joo-Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | memory dysfunction | - |
dc.subject.keywordAuthor | scopolamine | - |
dc.subject.keywordAuthor | cholinergic system | - |
dc.subject.keywordAuthor | nerve growth factor (NGF) | - |
dc.subject.keywordAuthor | cAMP response element-binding protein (CREB) | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordPlus | ELEMENT-BINDING PROTEIN | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | FRUIT SEEDS | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | ACETYLCHOLINE | - |
dc.subject.keywordPlus | DEFICITS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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