Diabetes-Free Survival in Patients Who Underwent Islet Autotransplantation After 50% to 60% Distal Partial Pancreatectomy for Benign Pancreatic Tumors
DC Field | Value | Language |
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dc.contributor.author | Jin, Sang-Man | - |
dc.contributor.author | Oh, Seung-Hoon | - |
dc.contributor.author | Kim, Soo Kyoung | - |
dc.contributor.author | Jung, Hye Seung | - |
dc.contributor.author | Choi, Seong-Ho | - |
dc.contributor.author | Jang, Kee-Taek | - |
dc.contributor.author | Lee, Kyu Taek | - |
dc.contributor.author | Kim, Jae Hyeon | - |
dc.contributor.author | Lee, Myung-Shik | - |
dc.contributor.author | Lee, Moon-Kyu | - |
dc.contributor.author | Kim, Kwang-Won | - |
dc.date.available | 2020-02-28T23:44:58Z | - |
dc.date.created | 2020-02-13 | - |
dc.date.issued | 2013-06-15 | - |
dc.identifier.issn | 0041-1337 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14471 | - |
dc.description.abstract | Background. Several retrospective studies with short-termfollow-up have demonstrated a low rate of new-onset diabetes after distal pancreatectomy for benign pancreatic tumors. We sought to determine the long-termdiabetes-free survival of patients who underwent islet autotransplantation (IAT) after distal pancreatectomy and to identify any associations between the isolation parameters of autologous islets and diabetes-free survival. Methods. Among the 37 nondiabetic patients who underwent 50% to 60% partial pancreatectomy, 20 underwent IAT (IAT group; median follow-up period, 61 months). In the IAT group, diabetes-free survival was determined based on annual oral glucose tolerance tests, fasting blood glucose, and hemoglobin A(1C). Results. The 7-year diabetes-free survival rate was 51% in the IAT group (median follow-up period, 61 months) and 45% in the 37 study subjects. Diabetes-free survival was significantly prolonged when islet yield per gram of pancreas weight was more than 5154 islet equivalents (IEQ)/g, even in patients with prediabetes and high insulin resistance who had a markedly high rate of diabetes development. The proportion of patients with impaired glucose tolerance at 2 years after distal pancreatectomy was 12 of 16 in the control group, 6 of 7 in patients with islet yields of less than 5154 IEQ/g, and 3 of 11 in patients with islet yields of more than 5154 IEQ/g (P=0.019). Conclusions. Partial (50%-60%) pancreatectomy for benign pancreatic tumors had a major metabolic consequence, especially in patients with prediabetes and high insulin resistance. In this setting, prolonged diabetes-free survival was observed in patients who underwent IAT when a high islet yield per gram of pancreas was achieved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | TRANSPLANTATION | - |
dc.subject | RESECTION | - |
dc.subject | OUTCOMES | - |
dc.title | Diabetes-Free Survival in Patients Who Underwent Islet Autotransplantation After 50% to 60% Distal Partial Pancreatectomy for Benign Pancreatic Tumors | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000330377400017 | - |
dc.identifier.doi | 10.1097/TP.0b013e31828c0c29 | - |
dc.identifier.bibliographicCitation | TRANSPLANTATION, v.95, no.11, pp.1396 - 1403 | - |
dc.identifier.scopusid | 2-s2.0-84879890895 | - |
dc.citation.endPage | 1403 | - |
dc.citation.startPage | 1396 | - |
dc.citation.title | TRANSPLANTATION | - |
dc.citation.volume | 95 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Kim, Kwang-Won | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Islet transplantation | - |
dc.subject.keywordAuthor | Pancreatectomy | - |
dc.subject.keywordAuthor | Islet isolation | - |
dc.subject.keywordPlus | RESECTION | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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