There is no evidence for an association between the serotonin receptor 3A gene C178T polymorphism and tardive dyskinesia in Korean schizophrenia patients
DC Field | Value | Language |
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dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.contributor.author | Yoon, Ho-Kyoung | - |
dc.contributor.author | Cho, Sung Nam | - |
dc.contributor.author | Park, Young-Min | - |
dc.contributor.author | Kim, Leen | - |
dc.date.available | 2020-02-28T23:45:29Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 0803-9488 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14492 | - |
dc.description.abstract | Background: Tardive dyskinesia (TD) is a potential adverse effect of long-term treatment with antipsychotics. Previous studies have suggested a link between brain serotonergic systems and TD vulnerability. A recent report described that a serotonin 3 receptor (5-HTR3) agonist induced rhythmic movements in mice with complete paraplegia. Furthermore, it has been reported that the 5-HTR3 antagonist ondansetron is efficacious in the treatment of Gilles de la Tourette syndrome (GTS). Aim: The aim of the present study was to determine whether the 5-HTR3A gene C178T polymorphism is associated with antipsychotic-induced TD in Korean schizophrenia patients. Methods: We investigated 280 Korean schizophrenia patients. Subjects with TD (n = 105) and without TD (n = 175) were matched for antipsychotic drug exposure and other relevant variables. Results: The distributions of genotypic (chi-squared = 3.55, p = 0.169) and allelic (chi-squared = 0.40, p = 0.528) frequencies did not differ between patients with and without TD. The total score on the Abnormal Involuntary Movement Scale also did not differ between the two genotype groups (F = 0.94, p = 0.391). Conclusions: The findings of the present study do not support the involvement of the 5-HTR3A gene C178T polymorphism in TD in Korean schizophrenia subjects. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | NORDIC JOURNAL OF PSYCHIATRY | - |
dc.subject | DOPAMINE D3 RECEPTOR | - |
dc.subject | SER9GLY POLYMORPHISM | - |
dc.subject | ONDANSETRON TREATMENT | - |
dc.subject | 5-HT2C RECEPTOR | - |
dc.subject | 2A RECEPTOR | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | CHINESE | - |
dc.subject | HTR3A | - |
dc.subject | CYP2D6 | - |
dc.subject | RISK | - |
dc.title | There is no evidence for an association between the serotonin receptor 3A gene C178T polymorphism and tardive dyskinesia in Korean schizophrenia patients | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000319077800011 | - |
dc.identifier.doi | 10.3109/08039488.2012.732114 | - |
dc.identifier.bibliographicCitation | NORDIC JOURNAL OF PSYCHIATRY, v.67, no.3, pp.214 - 218 | - |
dc.identifier.scopusid | 2-s2.0-84878103014 | - |
dc.citation.endPage | 218 | - |
dc.citation.startPage | 214 | - |
dc.citation.title | NORDIC JOURNAL OF PSYCHIATRY | - |
dc.citation.volume | 67 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kang, Seung-Gul | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Association | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Schizophrenia | - |
dc.subject.keywordAuthor | Serotonin receptor 3A gene | - |
dc.subject.keywordAuthor | Tardive dyskinesia | - |
dc.subject.keywordPlus | DOPAMINE D3 RECEPTOR | - |
dc.subject.keywordPlus | SER9GLY POLYMORPHISM | - |
dc.subject.keywordPlus | ONDANSETRON TREATMENT | - |
dc.subject.keywordPlus | 5-HT2C RECEPTOR | - |
dc.subject.keywordPlus | 2A RECEPTOR | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | CHINESE | - |
dc.subject.keywordPlus | HTR3A | - |
dc.subject.keywordPlus | CYP2D6 | - |
dc.subject.keywordPlus | RISK | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
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