CD26/DPP4 Levels in Peripheral Blood and T Cells in Patients With Type 2 Diabetes Mellitus
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Ah | - |
dc.contributor.author | Kim, Young Ree | - |
dc.contributor.author | Yang, Eun Jin | - |
dc.contributor.author | Kwon, Eun-Jeong | - |
dc.contributor.author | Kim, Sun Hyung | - |
dc.contributor.author | Kang, Sung Ha | - |
dc.contributor.author | Park, Doek Bae | - |
dc.contributor.author | Oh, Byung-Chul | - |
dc.contributor.author | Kim, Jinseok | - |
dc.contributor.author | Heo, Sang Taek | - |
dc.contributor.author | Koh, Gwanpyo | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.date.available | 2020-02-28T23:45:30Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14493 | - |
dc.description.abstract | Context: Dipeptidyl peptidase 4 (CD26/DPP4) is expressed on blood T cells and also circulates in a soluble form (sCD26/DPP4). Objective: We aimed to evaluate blood T cell and circulating CD26/DPP4 and its association with metabolic parameters in patients with type 2 diabetes mellitus (T2DM). Designs: We measured CD26/DPP4 expression (percentage of CD26(+) cells using flow cytometry) on CD4(+) and CD8(+) T cells, serum CD26/DPP4 level and activity, and various metabolic parameters in T2DM patients not on DPP4 inhibitor therapy (n = 148). Nondiabetic subjects (n = 50) were included as a control group. Results: Compared with the healthy controls, CD26/DPP4 expression on CD4(+) T cells and CD8(+) T cells was higher in T2DM patients. Serum CD26/DPP4 levels and enzymatic activities were also higher in patients with T2DM than in the control group only when metformin and/or thiazolidinedione-treated T2DM patients were excluded; metformin and/or thiazolidinedione-treated T2DM patients had lower values compared with other T2DM patients. Various parameters in T2DM patients were related to CD26/DPP4 expression on the T cells (hemoglobin A1c), serum sCD26/DPP4 (hemoglobin A1c and insulin resistance assessed by updated homeostasis model assessment), and serum CD26/DPP4 activity (insulin resistance assessed by updated homeostasis model assessment, gamma-glutamyl transferase, and alanine aminotransferase) by multivariate analyses. After active glucose control for 12 weeks in drug-naive T2DM patients (n = 50), CD26/DPP4 expression on blood T cells was significantly decreased. Conclusions: Our results suggest that the CD26/DPP4 level on blood T cells was associated with glucose control status in patients with T2DM. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ENDOCRINE SOC | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.subject | DIPEPTIDYL PEPTIDASE-IV | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | LYMPHOCYTES-T | - |
dc.subject | EXPRESSION | - |
dc.subject | CD26 | - |
dc.subject | INFLAMMATION | - |
dc.subject | SERUM | - |
dc.subject | OBESITY | - |
dc.subject | ACTIVATION | - |
dc.title | CD26/DPP4 Levels in Peripheral Blood and T Cells in Patients With Type 2 Diabetes Mellitus | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000319736500064 | - |
dc.identifier.doi | 10.1210/jc.2012-4288 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v.98, no.6, pp.2553 - 2561 | - |
dc.identifier.scopusid | 2-s2.0-84878485447 | - |
dc.citation.endPage | 2561 | - |
dc.citation.startPage | 2553 | - |
dc.citation.title | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.citation.volume | 98 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Oh, Byung-Chul | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DIPEPTIDYL PEPTIDASE-IV | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | LYMPHOCYTES-T | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CD26 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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