Disruption of the Cereblon Gene Enhances Hepatic AMPK Activity and Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Kwang Min | - |
dc.contributor.author | Yang, Seung-Joo | - |
dc.contributor.author | Kim, Yong Deuk | - |
dc.contributor.author | Choi, Yoo Duk | - |
dc.contributor.author | Nam, Jong Hee | - |
dc.contributor.author | Choi, Cheol Soo | - |
dc.contributor.author | Choi, Hueng-Sik | - |
dc.contributor.author | Park, Chul-Seung | - |
dc.date.available | 2020-02-28T23:45:34Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14498 | - |
dc.description.abstract | A nonsense mutation in cereblon (CRBN) causes a mild type of mental retardation in humans. An earlier study showed that CRBN negatively regulates the functional activity of AMP-activated protein kinase (AMPK) in vitro by binding directly to the alpha 1-subunit of the AMPK complex. However, the in vivo role of CRBN was not stuclied. For elucidation of the physiological functions of Crbn, a mouse strain was generated in which the Crbn gene was deleted throughout the whole body. In Crbn-deficient mice fed a normal diet, AMPK in the liver showed hyperphosphorylation, which indicated the constitutive activation of AMPK. Since Crbn-deficient mice showed significantly less weight gain when fed a high-fat diet and their insulin sensitivity was considerably improved, the functions of Crbn in the liver were primarily investigated. These results provide the first in vivo evidence that Crbn is a negative modulator of AMPK, which suggests that Crbn may be a potential target for metabolic disorders of the liver. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER DIABETES ASSOC | - |
dc.relation.isPartOf | DIABETES | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | RAT-LIVER | - |
dc.subject | IDENTIFICATION | - |
dc.subject | ENERGY | - |
dc.subject | EXPRESSION | - |
dc.subject | GLUCOSE | - |
dc.subject | TARGET | - |
dc.subject | ENZYME | - |
dc.subject | BRAIN | - |
dc.title | Disruption of the Cereblon Gene Enhances Hepatic AMPK Activity and Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000319845000015 | - |
dc.identifier.doi | 10.2337/db12-1030 | - |
dc.identifier.bibliographicCitation | DIABETES, v.62, no.6, pp.1855 - 1864 | - |
dc.identifier.scopusid | 2-s2.0-84878257427 | - |
dc.citation.endPage | 1864 | - |
dc.citation.startPage | 1855 | - |
dc.citation.title | DIABETES | - |
dc.citation.volume | 62 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Choi, Cheol Soo | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | RAT-LIVER | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ENERGY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | ENZYME | - |
dc.subject.keywordPlus | BRAIN | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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