2 '',4 ''-O-Diacetylquercitrin, a Novel Advanced Glycation End-Product Formation and Aldose Reductase Inhibitor from Melastoma sanguineum
- Authors
- Lee, Ik-Soo; Kim, Il Soon; Lee, Yun Mi; Lee, Youngseop; Kim, Joo-Hwan; Kim, Jin Sook
- Issue Date
- Jun-2013
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Melastonia sanguineum; flavonoid; advanced glycation end-product; rat lens aldose reductase
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.61, no.6, pp.662 - 665
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Volume
- 61
- Number
- 6
- Start Page
- 662
- End Page
- 665
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14508
- DOI
- 10.1248/cpb.c12-00877
- ISSN
- 0009-2363
- Abstract
- A new flavonoid, 2,'' 4 ''-O-diacetylquercitrin (1), along with six known flavonoids (2-7) were isolated from the aerial parts of Melastoma sanguineunz. The structure of the new flavonoid was established by extensive spectroscopic studies and chemical evidence. The inhibitory effects of isolated compounds (1-7) on advanced glycation end-products (AGEs) formation and rat lens aldose reductase (RLAR) in vitro were examined. Of the tested compounds, compound 1 was the strongest inhibitor of AGEs, with an IC50 of 11.46 +/- 0.44 mu m. In the RLAR assay, all tested compounds exhibited greater inhibitory effects on RLAR than that of a positive control, 3,3-tetramethyleneglutaric acid (10(50)=28.8 +/- 1.5 mu m); compound 1 exhibited the strongest RLAR-inhibitory activity, with an IC50 of 0.077 +/- 0.003 mu m.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 생명과학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.