Silica Coated Gold Nanorods for Imaging and Photo-Thermal Therapy of Cancer Cells
- Authors
- Mallick, Sudipta; Sun, In-Cheol; Kim, Kwangmeyung; Yi, Dong Kee
- Issue Date
- May-2013
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Au-Nanorods; Surface Functionalization; Photo-Thermal Therapy
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.13, no.5, pp.3223 - 3229
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Volume
- 13
- Number
- 5
- Start Page
- 3223
- End Page
- 3229
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14553
- DOI
- 10.1166/jnn.2013.7149
- ISSN
- 1533-4880
- Abstract
- Due to their efficient conversion of absorbed light energy to heat gold nanorods have been proved to be an amazing tool for minimally invasive photo-thermal cancer therapy. The present in vitro study demonstrates the ability of silica coated Au nanorods to function as a dual probe for cancer-cell therapy and imaging without any toxic side-effects. HeLa cells were incubated with silica coated Au nanorods and imaged inside the cell just after 1 hour of incubation by a dark field set up due to strong surface enhanced Raman scattering. To induce hyperthermia, silica coated Au nanorod incubated HeLa cells were illuminated with a diode laser (671 nm, 200 mW, 10 min). Cell destruction was observed even at a very low dose of nanorods, whereas none was observed in the absence of nanorods. Silica coated Au nanorods thus offer a promising, novel class of selective photo-thermal agents for cancer therapy and diagnosis.
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