Reduced Beta-Catenin Expression in the Hippocampal CA1 Region Following Transient Cerebral Ischemia in the Gerbil
DC Field | Value | Language |
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dc.contributor.author | Cho, Jeong-Hwi | - |
dc.contributor.author | Yan, Bing Chun | - |
dc.contributor.author | Lee, Young Joo | - |
dc.contributor.author | Park, Joon Ha | - |
dc.contributor.author | Ahn, Ji Hyeon | - |
dc.contributor.author | Kim, In Hye | - |
dc.contributor.author | Lee, Jae-Chul | - |
dc.contributor.author | Kim, Young-Myeong | - |
dc.contributor.author | Lee, Bonghee | - |
dc.contributor.author | Cho, Jun Hwi | - |
dc.contributor.author | Won, Moo-Ho | - |
dc.date.available | 2020-02-28T23:47:06Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-05 | - |
dc.identifier.issn | 0364-3190 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14567 | - |
dc.description.abstract | Beta-catenin, a transcription factor, plays a critical role in cell survival and degradation after stroke. In this study, we examined changes of expression in beta-catenin in the hippocampal CA1 region of the gerbil following 5 min of transient cerebral ischemia. We observed neuronal damage using cresyl violet staining, neuronal nuclei immunohistochemistry and Fluro-Jade B immunofluorescence. Four days after ischemia-reperfusion (I-R), most of pyramidal cells in the CA1 region were damaged. In addition, early damage in dendrites was detected 1 day after I-R by immunohistochemical staining for microtubule-associated protein 2 (MAP-2), and MAP-2 immunoreactivity was hardly detected in the CA1 region 4 days after I-R. We found that beta-catenin (a synapse-enriched cell adhesion molecule) was well expressed in dendrites before I-R. Its immunoreactivity was well colocalized with MAP-2. Chronological change of beta-catenin immunoreactivity was novelty in the present study. Twelve hours after I-R, its immunoreactivity was decreased in the stratum radiatum of the CA1 region, however, its immunoreactivity was increased 1 and 2 days after I-R, and decreased sharply 4 days after I-R. However, we did not find any change in beta-catenin immunoreactivity in the CA2 and CA3 region. In brief, we suggest that early change of beta-catenin expression in the stratum pyramidale of ischemic hippocampal CA1 region is associated with early dendrite damage following transient cerebral ischemia. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | - |
dc.relation.isPartOf | NEUROCHEMICAL RESEARCH | - |
dc.subject | MICROTUBULE-ASSOCIATED PROTEIN-2 | - |
dc.subject | DELAYED NEURONAL DEATH | - |
dc.subject | FOCAL ISCHEMIA | - |
dc.subject | RAT-BRAIN | - |
dc.subject | NEUROGENESIS | - |
dc.subject | DEGENERATION | - |
dc.subject | REPERFUSION | - |
dc.subject | DEGRADATION | - |
dc.subject | UVOMORULIN | - |
dc.subject | FOREBRAIN | - |
dc.title | Reduced Beta-Catenin Expression in the Hippocampal CA1 Region Following Transient Cerebral Ischemia in the Gerbil | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000316903200016 | - |
dc.identifier.doi | 10.1007/s11064-013-1015-2 | - |
dc.identifier.bibliographicCitation | NEUROCHEMICAL RESEARCH, v.38, no.5, pp.1045 - 1054 | - |
dc.identifier.scopusid | 2-s2.0-84876192291 | - |
dc.citation.endPage | 1054 | - |
dc.citation.startPage | 1045 | - |
dc.citation.title | NEUROCHEMICAL RESEARCH | - |
dc.citation.volume | 38 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Lee, Bonghee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Ischemia-reperfusion injury | - |
dc.subject.keywordAuthor | Dendrite damage | - |
dc.subject.keywordAuthor | Microtubule-associated protein 2 | - |
dc.subject.keywordAuthor | Synaptic plasticity | - |
dc.subject.keywordAuthor | Beta-catenin | - |
dc.subject.keywordPlus | MICROTUBULE-ASSOCIATED PROTEIN-2 | - |
dc.subject.keywordPlus | DELAYED NEURONAL DEATH | - |
dc.subject.keywordPlus | FOCAL ISCHEMIA | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.subject.keywordPlus | NEUROGENESIS | - |
dc.subject.keywordPlus | DEGENERATION | - |
dc.subject.keywordPlus | REPERFUSION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | UVOMORULIN | - |
dc.subject.keywordPlus | FOREBRAIN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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