Nocapyrones H-J, 3,6-Disubstituted alpha-Pyrones from the Marine Actinomycete Nocardiopsis sp KMF-001
DC Field | Value | Language |
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dc.contributor.author | Kim, Min Cheol | - |
dc.contributor.author | Kwon, Oh-Wook | - |
dc.contributor.author | Park, Jin-Soo | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Kwon, Hak Cheol | - |
dc.date.available | 2020-02-28T23:47:20Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-05 | - |
dc.identifier.issn | 0009-2363 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14580 | - |
dc.description.abstract | Three new 3,6-disubstituted alpha-pyrones, nocapyrones H-J (1-3), were isolated from the marine actinomycete Nocardiopsis sp. KMF-001. Their structures were assigned to be 3-alkylated 6-(1-methyl-1-propenyl)-2H-pyran-2-ones on the basis of UV, MS, NMR, and high resolution (HR)-FAB-MS analyses. Nocapyrone H (1) reduced the pro-inflammatory factor such as nitric oxide (NO), prostaglandin E-2 (PGE(2)) and interleukin-1 beta (IL-1 beta). Moreover, nocapyrone H showed 5.82% stronger inhibitory effect on NO production than chrysin at a concentration of 10 mu M in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.relation.isPartOf | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | SP-NOV. | - |
dc.subject | NEUROPROTECTIVE ROLE | - |
dc.subject | NATURAL-PRODUCTS | - |
dc.subject | IMMUNE-SYSTEM | - |
dc.subject | A-D | - |
dc.subject | MICROGLIA | - |
dc.subject | NEUROTOXICITY | - |
dc.subject | DERIVATIVES | - |
dc.subject | INHIBITORS | - |
dc.title | Nocapyrones H-J, 3,6-Disubstituted alpha-Pyrones from the Marine Actinomycete Nocardiopsis sp KMF-001 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000318331300003 | - |
dc.identifier.doi | 10.1248/cpb.c12-00956 | - |
dc.identifier.bibliographicCitation | CHEMICAL & PHARMACEUTICAL BULLETIN, v.61, no.5, pp.511 - 515 | - |
dc.identifier.scopusid | 2-s2.0-84878772964 | - |
dc.citation.endPage | 515 | - |
dc.citation.startPage | 511 | - |
dc.citation.title | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 61 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | nocapyrone H | - |
dc.subject.keywordAuthor | nocapyrone I | - |
dc.subject.keywordAuthor | nocapyrone J | - |
dc.subject.keywordAuthor | Nocardiopsis sp. | - |
dc.subject.keywordAuthor | neuro-protective effect | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | SP-NOV. | - |
dc.subject.keywordPlus | NEUROPROTECTIVE ROLE | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | IMMUNE-SYSTEM | - |
dc.subject.keywordPlus | A-D | - |
dc.subject.keywordPlus | MICROGLIA | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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