Nocapyrones H-J, 3,6-Disubstituted alpha-Pyrones from the Marine Actinomycete Nocardiopsis sp KMF-001

Abstract

Three new 3,6-disubstituted alpha-pyrones, nocapyrones H-J (1-3), were isolated from the marine actinomycete Nocardiopsis sp. KMF-001. Their structures were assigned to be 3-alkylated 6-(1-methyl-1-propenyl)-2H-pyran-2-ones on the basis of UV, MS, NMR, and high resolution (HR)-FAB-MS analyses. Nocapyrone H (1) reduced the pro-inflammatory factor such as nitric oxide (NO), prostaglandin E-2 (PGE(2)) and interleukin-1 beta (IL-1 beta). Moreover, nocapyrone H showed 5.82% stronger inhibitory effect on NO production than chrysin at a concentration of 10 mu M in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.