The control of cell adhesion on a PMMA polymer surface consisting of nanopillar arrays
- Authors
- Ahn, Jaehwan; Son, Sang Jun; Min, Junhong
- Issue Date
- 15-Apr-2013
- Publisher
- ELSEVIER
- Keywords
- Nanopillars; Anodic aluminum oxide; Epithelial cells; Cell adhesion; Photolithography
- Citation
- JOURNAL OF BIOTECHNOLOGY, v.164, no.4, pp.543 - 548
- Journal Title
- JOURNAL OF BIOTECHNOLOGY
- Volume
- 164
- Number
- 4
- Start Page
- 543
- End Page
- 548
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14617
- DOI
- 10.1016/j.jbiotec.2012.12.017
- ISSN
- 0168-1656
- Abstract
- We investigated the effect of arrayed nanostructures on the cell adhesion rate by forming nanopillars on a PMMA polymer surface, and demonstrated cell patterning tools for the polymer surface without biological or chemical reagents. Nanopillar arrayed structures with various heights (0, 50, 100, 150, and 200 nm with 50 nm of pitch size and 60 nm of diameter) were formed on a PMMA surface by using nano-molding techniques with nanoporous AAO (anodic aluminum oxide) as a template. The nanopillar arrayed structures provide negative effects on the cell adhesion on the non-treated PMMA (moderate hydrophobic, >= 80 degrees of contact angle), whereas slightly positive and no effects were shown by nanopillar structures on plasma (hydrophilic, <= 20 degrees) and silane-treated PMMA (moderate, 40-70 degrees), respectively. The microstructure on the polymer surface showed a 20% positive effect on the cell adhesion rate. As a result, nano or micro patterning structures could control the cell adhesion rate (15-120%) and it enabled the formation of closed cell patterns on the PMMA surface without chemical or biological surface treatments. (C) 2013 Elsevier B. V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 나노화학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14617)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.