Quinic acid derivatives from Pimpinella brachycarpa exert anti-neuroinflammatory activity in lipopolysaccharide-induced microglia
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung Young | - |
dc.contributor.author | Moon, Eunjung | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-28T23:48:18Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-04-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14619 | - |
dc.description.abstract | Five new quinic acid derivatives (1-5), together with 10 known quinic acid derivatives (6-15), were isolated from the MeOH extract of Pimpinella brachycarpa (Umbelliferae). Their structures were established on the basis of spectroscopic analyses including extensive 2D NMR studies (COSY, HMQC and HMBC). Isolated compounds 1-15 were evaluated for their inhibitory activities on nitric oxide (NO) production in an activated murine microglial cell line. Compounds 2, 3, 8 and 11 significantly inhibited NO production without high cell toxicity in lipopolysaccharide (LPS)-activated BV-2 cells, a microglia cell line (IC50 = 4.66, 12.52, 9.04 and 12.11 mu M, respectively). (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.subject | PHENOLIC-COMPOUNDS | - |
dc.subject | CHLOROGENIC ACID | - |
dc.subject | IDENTIFICATION | - |
dc.subject | CONSTITUENTS | - |
dc.subject | GLYCOSIDES | - |
dc.subject | LEAVES | - |
dc.title | Quinic acid derivatives from Pimpinella brachycarpa exert anti-neuroinflammatory activity in lipopolysaccharide-induced microglia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000316642900045 | - |
dc.identifier.doi | 10.1016/j.bmcl.2013.01.115 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.7, pp.2140 - 2144 | - |
dc.identifier.scopusid | 2-s2.0-84875225622 | - |
dc.citation.endPage | 2144 | - |
dc.citation.startPage | 2140 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 23 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Moon, Eunjung | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Pimpinella brachycarpa | - |
dc.subject.keywordAuthor | Umbelliferae | - |
dc.subject.keywordAuthor | Quinic acid derivative | - |
dc.subject.keywordAuthor | Anti-inflammatory effect | - |
dc.subject.keywordPlus | PHENOLIC-COMPOUNDS | - |
dc.subject.keywordPlus | CHLOROGENIC ACID | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordPlus | LEAVES | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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