Effect of estradiol on the expression of renal sodium transporters in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Heo, N. J. | - |
dc.contributor.author | Son, M. -J. | - |
dc.contributor.author | Lee, J. W. | - |
dc.contributor.author | Jung, J. Y. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Oh, Y. K. | - |
dc.contributor.author | Na, K. Y. | - |
dc.contributor.author | Yoon, H. -J. | - |
dc.contributor.author | Joo, K. W. | - |
dc.contributor.author | Han, J. S. | - |
dc.date.available | 2020-02-29T00:41:44Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 1369-7137 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14634 | - |
dc.description.abstract | Background Although estradiol has been thought to perform an important role in blood pressure regulation, the effects of estradiol on the expression of renal sodium transporters are not fully understood. Methods Female Sprague-Dawley rats were treated with 17 beta-estradiol or vehicle for 10 days after ovariectomy, and after both ovariectomy and adrenalectomy to eliminate the effect of aldosterone. Results In the ovariectomized (OVX) rats, estradiol decreased the abundance of the Na-K-2Cl cotransporter (NKCC2) (31.5% of control (OVX), p < 0.01), Na-Cl cotransporter (NCC) proteins (40.5% of control (OVX), p < 0.01) and alpha- and gamma-subunits of the epithelial sodium channel (ENaC) (44.7% and 11.0% of control (OVX), p < 0.01). Estradiol also reduced plasma aldosterone levels (OVX + 17 beta-estradiol vs. OVX, 116.3 +/- 44.4 vs. 184.2 +/- 33.4 pmol/l, p < 0.05) and systolic blood pressure (OVX + 17 beta-estradiol vs. OVX, 115 +/- 4 vs. 132 +/- 2 mmHg, p < 0.05). In rats having undergone adrenalectomy and ovariectomy, estradiol did not reduce systolic blood pressure, or the expression of sodium transporters. Conclusion Estradiol decreased systolic blood pressure, plasma aldosterone levels, and the expression of renal sodium transporters. After aldosterone was eliminated, estradiol did not affect blood pressure or the expression of sodium transporters, which indicates that the effect of estradiol on the renal sodium transporters is at least partly influenced by aldosterone. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | INFORMA HEALTHCARE | - |
dc.relation.isPartOf | CLIMACTERIC | - |
dc.subject | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject | ESTROGEN PLUS PROGESTIN | - |
dc.subject | BLOOD-PRESSURE | - |
dc.subject | POSTMENOPAUSAL WOMEN | - |
dc.subject | OVARIECTOMIZED RATS | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | SEX-DIFFERENCES | - |
dc.subject | ANGIOTENSIN-II | - |
dc.subject | ALDOSTERONE | - |
dc.subject | HEALTH | - |
dc.title | Effect of estradiol on the expression of renal sodium transporters in rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000316190900012 | - |
dc.identifier.doi | 10.3109/13697137.2012.672494 | - |
dc.identifier.bibliographicCitation | CLIMACTERIC, v.16, no.2, pp.265 - 273 | - |
dc.identifier.scopusid | 2-s2.0-84875183276 | - |
dc.citation.endPage | 273 | - |
dc.citation.startPage | 265 | - |
dc.citation.title | CLIMACTERIC | - |
dc.citation.volume | 16 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Jung, J. Y. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | ESTROGEN | - |
dc.subject.keywordAuthor | SODIUM | - |
dc.subject.keywordAuthor | KIDNEY | - |
dc.subject.keywordAuthor | ALDOSTERONE | - |
dc.subject.keywordAuthor | EPITHELIAL SODIUM CHANNEL | - |
dc.subject.keywordAuthor | HYPERTENSION | - |
dc.subject.keywordAuthor | SEX STEROIDS | - |
dc.subject.keywordPlus | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | ESTROGEN PLUS PROGESTIN | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | POSTMENOPAUSAL WOMEN | - |
dc.subject.keywordPlus | OVARIECTOMIZED RATS | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | SEX-DIFFERENCES | - |
dc.subject.keywordPlus | ANGIOTENSIN-II | - |
dc.subject.keywordPlus | ALDOSTERONE | - |
dc.subject.keywordPlus | HEALTH | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.