Intubation time required for tracheal intubation with low-dose rocuronium in children with and without atropine
- Authors
- Kwak, Hyun Jeong; Min, Sang Kee; Moon, Bong Ki; Lee, Kyung Cheon; Kim, Yong Beom; Kim, Jong Yeop
- Issue Date
- Apr-2013
- Publisher
- SPRINGER JAPAN KK
- Keywords
- Atropine; Low-dose rocuronium; Intubation
- Citation
- JOURNAL OF ANESTHESIA, v.27, no.2, pp.199 - 204
- Journal Title
- JOURNAL OF ANESTHESIA
- Volume
- 27
- Number
- 2
- Start Page
- 199
- End Page
- 204
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14655
- DOI
- 10.1007/s00540-012-1489-0
- ISSN
- 0913-8668
- Abstract
- The purpose of this study was to determine the intubation time needed to facilitate tracheal intubation (Time(EI)) with a low dose of rocuronium (0.3 mg/kg) during propofol induction, and to determine whether this time was reduced by the administration of atropine. Forty-six children, aged 3-10 years, were randomly assigned to receive either saline (control group) or atropine 10 mu g/kg (atropine group). Anesthesia was induced with alfentanil 10 mu g/kg, propofol 2.5 mg/kg, and rocuronium 0.3 mg/kg. Each Time(EI) at which tracheal intubation was attempted was predetermined according to the up-and-down method. The values of Time(EI) that provided excellent intubation conditions in 50 and 95 % of patients were defined as Time(EI)50 and Time(EI)95, respectively. Time(EI)50 +/- A SD was 160 +/- A 26.2 and 150 +/- A 13.7 s in the control and atropine groups, respectively. Using isotonic regression, Time(EI)95 in the control and atropine groups was 199 s (95 % CI 198.8-200.7 s) and 171 s (95 % CI 171.3-172.1 s), respectively. Time(EI)95 was significantly higher in the control group than in the atropine group (P < 0.001). HR was significantly higher in the atropine group than in the control group during the study period. This study demonstrated that the Time(EI)95 of a low dose of rocuronium (0.3 mg/kg) required for excellent tracheal intubation was 199 s during i.v. anesthesia induction using propofol and alfentanil in children. Also, i.v. atropine (10 mu g/kg) before anesthesia induction was able to reduce Time(EI)95 by 28 s.
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