Relationships between serum osteocalcin, leptin and the effect of weight loss by pharmacological treatment in healthy, nonsmoking Korean obese adults
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Suh, Heuy-sun | - |
dc.contributor.author | Hwang, In-cheol | - |
dc.contributor.author | Lee, Kyung-sik | - |
dc.contributor.author | Kim, Kyoung Kon | - |
dc.date.available | 2020-02-29T00:42:49Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-03-15 | - |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14685 | - |
dc.description.abstract | Background: Recent studies have reported a relationship between osteocalcin (OC) levels and factors associated with energy metabolism and insulin resistance. As any detailed understanding of OC mechanisms still remains elusive, this study aimed at revealing a correlation between serum DC levels and obesity in healthy, nonsmoking, Korean obese adults who had undergone weight loss through pharmacological treatment. Methods: 119 healthy, nonsmoking, Korean obese adults were investigated at 3 months following weight loss through pharmacological treatment. Serum OC, leptin, HOMA score, ghrelin, visceral fat mass, total body fat, and BMI were measured. Results: Increase in serum OC was significantly associated with decreases in: BMI (and weight change %) (r=-0.209, p=0.023), visceral fat mass (r=-0.189, p=0.049), HOMA (r=-0.203 p=0.027), and leptin (r=-0.253 p=0.006), but not with changes in adiponectin (r=+0.029, p=NS), and Ghrelin (r=+0.019, p=NS). Decrease in leptin (beta=-0.280, p=0.002) was significantly associated with an increase in serum OC, after pharmacological weight loss treatment was adjusted for age, sex, drug type, and BMI (or visceral fat mass). Conclusions: Serum OC was significantly increased at 3 months after pharmacological weight loss. We further found that leptin levels were associated with changes in serum OC. These findings suggest a relationship between bone and adipose tissue. (C) 2013 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | CLINICA CHIMICA ACTA | - |
dc.subject | BONE MASS | - |
dc.subject | UNDERCARBOXYLATED OSTEOCALCIN | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | PLASMA-GLUCOSE | - |
dc.subject | FAT MASS | - |
dc.subject | METABOLISM | - |
dc.subject | SKELETON | - |
dc.subject | GHRELIN | - |
dc.subject | MARKERS | - |
dc.subject | DIFFERENTIATION | - |
dc.title | Relationships between serum osteocalcin, leptin and the effect of weight loss by pharmacological treatment in healthy, nonsmoking Korean obese adults | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000316530500004 | - |
dc.identifier.doi | 10.1016/j.cca.2012.11.029 | - |
dc.identifier.bibliographicCitation | CLINICA CHIMICA ACTA, v.418, pp.17 - 21 | - |
dc.identifier.scopusid | 2-s2.0-84872808087 | - |
dc.citation.endPage | 21 | - |
dc.citation.startPage | 17 | - |
dc.citation.title | CLINICA CHIMICA ACTA | - |
dc.citation.volume | 418 | - |
dc.contributor.affiliatedAuthor | Suh, Heuy-sun | - |
dc.contributor.affiliatedAuthor | Hwang, In-cheol | - |
dc.contributor.affiliatedAuthor | Lee, Kyung-sik | - |
dc.contributor.affiliatedAuthor | Kim, Kyoung Kon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Osteocalcin (OC) | - |
dc.subject.keywordAuthor | Leptin | - |
dc.subject.keywordAuthor | Adiponectin | - |
dc.subject.keywordAuthor | HOMA score | - |
dc.subject.keywordAuthor | Weight loss | - |
dc.subject.keywordPlus | BONE MASS | - |
dc.subject.keywordPlus | UNDERCARBOXYLATED OSTEOCALCIN | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | PLASMA-GLUCOSE | - |
dc.subject.keywordPlus | FAT MASS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | SKELETON | - |
dc.subject.keywordPlus | GHRELIN | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.