Islet allograft rejection in sensitized mice is refractory to control by combination therapy of immune-modulating agents
DC Field | Value | Language |
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dc.contributor.author | Hong, Juho | - |
dc.contributor.author | Yeom, Hye Jung | - |
dc.contributor.author | Lee, Eunwon | - |
dc.contributor.author | Han, Kyu Hyun | - |
dc.contributor.author | Koo, Tai Yeon | - |
dc.contributor.author | Cho, Bumrae | - |
dc.contributor.author | Ro, Han | - |
dc.contributor.author | Oh, Kook Hwan | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Yang, Jaeseok | - |
dc.date.available | 2020-02-29T00:43:10Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-03 | - |
dc.identifier.issn | 0966-3274 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14696 | - |
dc.description.abstract | Retransplantation is common in allogeneic islet transplantation, and therefore, memory responses in previously sensitized recipients present a distinct obstacle for successful islet transplantation. Given the difficulties in controlling memory responses contributing to allograft rejection, it is worth investigating the effects of new immune-modulating agents against islet allograft rejection in the sensitized recipients. In this study, we investigated immune-modulating agents including 5-azacytidine and IL-2/anti-IL-2 complex to ascertain their suppressive effects on memory responses. In suppression assays, rapamycin effectively suppressed the proliferation of memory T cells, whereas 5-azacytidine, a methylation inhibitor suppressed the survival and proliferation of memory T cells. Combination therapy of anti-CD40L, anti-OX40L, and rapamycin slightly prolonged BALB/c islet allograft survival in sensitized C57BL6 mice, and reduced intragraft infiltration of macrophages, T cells, and B cells. However, the addition of IL-2/anti-IL-2 complex, an inducer of regulatory T cells, did not exhibit additional suppression against rejection in sensitized mice. Although a combination of 5-azacytidine and rapamycin markedly suppressed islet allograft rejection in naive mice, it failed to achieve long-term graft survival even when combined with anti-CD40L and anti-OX40 in sensitized mice. In short, 5-azacytidine-based or IL-2/anti-IL-2 complex-based regimens can suppress islet allograft rejection in naive recipients, but fail to control islet allograft rejection in sensitized recipients. (C) 2013 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | TRANSPLANT IMMUNOLOGY | - |
dc.subject | GRAFT-SURVIVAL | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | MEMORY | - |
dc.subject | ACCEPTANCE | - |
dc.subject | COMPLEXES | - |
dc.subject | BLOCKADE | - |
dc.subject | CELLS | - |
dc.title | Islet allograft rejection in sensitized mice is refractory to control by combination therapy of immune-modulating agents | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000319484400005 | - |
dc.identifier.doi | 10.1016/j.trim.2013.01.005 | - |
dc.identifier.bibliographicCitation | TRANSPLANT IMMUNOLOGY, v.28, no.2-3, pp.86 - 92 | - |
dc.identifier.scopusid | 2-s2.0-84879795442 | - |
dc.citation.endPage | 92 | - |
dc.citation.startPage | 86 | - |
dc.citation.title | TRANSPLANT IMMUNOLOGY | - |
dc.citation.volume | 28 | - |
dc.citation.number | 2-3 | - |
dc.contributor.affiliatedAuthor | Ro, Han | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 5-Azacytidine | - |
dc.subject.keywordAuthor | IL-2/anti-IL-2 complex | - |
dc.subject.keywordAuthor | Islet transplantation | - |
dc.subject.keywordAuthor | Memory | - |
dc.subject.keywordAuthor | Sensitization | - |
dc.subject.keywordPlus | GRAFT-SURVIVAL | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | ACCEPTANCE | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | BLOCKADE | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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