Phenolic Constituents from the Twigs of Euonymus alatus and Their Cytotoxic and Anti-inflammatory Activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Ha, Sang Keun | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-29T00:44:01Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-03 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14734 | - |
dc.description.abstract | A bioassay-guided fractionation and chemical investigation of the MeOH extract of the twigs of Euonymus alatus resulted in the isolation and identification of five new phenolic compounds, named alatusols A-E (1-5), together with six known compounds (6-11). The structures of these new compounds were elucidated through spectral analysis, including extensive 2D-NMR data, and their absolute configurations were determined by the modified Mosher's method. Compounds 1-3 and 7-9 showed consistent cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values of 15.20-29.81 mu M. In addition, compounds 5 and 7 inhibited nitric oxide production in lipopolysaccharide-activated BV-2 cells with IC50 values of 22.77 and 32.52 mu M, respectively. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.relation.isPartOf | PLANTA MEDICA | - |
dc.subject | CAFFEIC ACID | - |
dc.subject | GROWTH | - |
dc.title | Phenolic Constituents from the Twigs of Euonymus alatus and Their Cytotoxic and Anti-inflammatory Activity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000316800900009 | - |
dc.identifier.doi | 10.1055/s-0032-1328286 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.79, no.5, pp.361 - 364 | - |
dc.identifier.scopusid | 2-s2.0-84875734441 | - |
dc.citation.endPage | 364 | - |
dc.citation.startPage | 361 | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 79 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Euonymus alatus | - |
dc.subject.keywordAuthor | Celastraceae | - |
dc.subject.keywordAuthor | phenylglycerol derivatives | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | anti-neuroinflammation | - |
dc.subject.keywordPlus | CAFFEIC ACID | - |
dc.subject.keywordPlus | GROWTH | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.