Novel suppressive effects of cardamonin on the activity and expression of transglutaminase-2 lead to blocking the migration and invasion of cancer cells
DC Field | Value | Language |
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dc.contributor.author | Park, Mi Kyung | - |
dc.contributor.author | Jo, Seung Ho | - |
dc.contributor.author | Lee, Hye Ja | - |
dc.contributor.author | Kang, June Hee | - |
dc.contributor.author | Kim, You Ri | - |
dc.contributor.author | Kim, Hyun Ji | - |
dc.contributor.author | Lee, Eun Ji | - |
dc.contributor.author | Koh, Jae Young | - |
dc.contributor.author | Ahn, Kyung Ok | - |
dc.contributor.author | Jung, Kyung Chae | - |
dc.contributor.author | Oh, Seung Hyun | - |
dc.contributor.author | Kim, Soo Youl | - |
dc.contributor.author | Lee, Chang Hoon | - |
dc.date.available | 2020-02-29T00:44:07Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-02-07 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14742 | - |
dc.description.abstract | Aims: Alpinia kaisumadai was recently found in our previous study to have anti-migratory and anti-invasion activities against HT-1080 cells. However, the study did not demonstrate the exact component of Alpinia katsumadai with anti-migratory and anti-invasive activities. We tested the effects and relevant mechanism of cardamonin (CDN) on the migration and invasion of cancer cells. Main methods: Migration and invasion of cancer cells were measured using multi-well chambers. Zymography and Western blots were used to examine the effects of CDN on the activities of matrix metalloproteinases (MMPs) and expression of transglutaminase-2 (Tgase-2). Key findings: CDN, but not alpinetin, dose-dependently suppressed the migration and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced invasion of HT-1080 sarcoma cells. CDN suppressed the expression of Tgase-2, MMP-2, NF-kappa B and MMP-9 in HT-1080 cells, and suppressed MMP-2 and MMP-9 activities. Gene silencing of Tgase-2 suppressed the migration and invasion of HT-1080 cells and suppressed the activities of MMP-2 and MMP-9. Migration of various cancer cells having high levels of Tgase-2 were also inhibited by CDN. CDN and Alpinia katsumadai extracts also directly inhibited the activity of Tgase-2. Significance: CDN inhibits migration of several cancer cell lines expressing Tgase-2 via suppression of Tgase-2 expression and inhibition of Tgase-2 activity. The finding that CON has Tgase-2 inhibitory activity will give us a new scaffold or clue of pharmacophore for the development of more effective Tgase-2 inhibitors. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | LIFE SCIENCES | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | TISSUE-TRANSGLUTAMINASE | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | ALPINIA-KATSUMADAI | - |
dc.subject | TUMOR-METASTASIS | - |
dc.subject | RETINOIC ACID | - |
dc.subject | BREAST-CANCER | - |
dc.subject | UP-REGULATION | - |
dc.subject | INHIBITION | - |
dc.subject | INFLAMMATION | - |
dc.title | Novel suppressive effects of cardamonin on the activity and expression of transglutaminase-2 lead to blocking the migration and invasion of cancer cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000314329800010 | - |
dc.identifier.doi | 10.1016/j.lfs.2012.11.009 | - |
dc.identifier.bibliographicCitation | LIFE SCIENCES, v.92, no.2, pp.154 - 160 | - |
dc.identifier.scopusid | 2-s2.0-84872356718 | - |
dc.citation.endPage | 160 | - |
dc.citation.startPage | 154 | - |
dc.citation.title | LIFE SCIENCES | - |
dc.citation.volume | 92 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Oh, Seung Hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Cardamonin | - |
dc.subject.keywordAuthor | Transglutaminase-2 | - |
dc.subject.keywordAuthor | Matrix metalloproteinases | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | Migration | - |
dc.subject.keywordAuthor | Invasion | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | TISSUE-TRANSGLUTAMINASE | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | ALPINIA-KATSUMADAI | - |
dc.subject.keywordPlus | TUMOR-METASTASIS | - |
dc.subject.keywordPlus | RETINOIC ACID | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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