Chromosome 11-Centric Human Proteome Analysis of Human Brain Hippocampus Tissue
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Kyung-Hoon | - |
dc.contributor.author | Kim, Jin Young | - |
dc.contributor.author | Kim, Se-Young | - |
dc.contributor.author | Min, Hye Kyeong | - |
dc.contributor.author | Lee, Hyoung-Joo | - |
dc.contributor.author | Ji, In Jung | - |
dc.contributor.author | Kang, Taewook | - |
dc.contributor.author | Park, Gun Wook | - |
dc.contributor.author | An, Hyun Joo | - |
dc.contributor.author | Lee, Bonghee | - |
dc.contributor.author | Ravid, Rivka | - |
dc.contributor.author | Ferrer, Isidro | - |
dc.contributor.author | Chung, Chun Kee | - |
dc.contributor.author | Paik, Young-Ki | - |
dc.contributor.author | Hancock, William S. | - |
dc.contributor.author | Park, Young Mok | - |
dc.contributor.author | Yoo, Jong Shin | - |
dc.date.available | 2020-02-29T00:46:02Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 1535-3893 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14827 | - |
dc.description.abstract | Human chromosome 11 is the third gene-rich chromosome having 1304 protein-coding genes. According to the GeneCards, this chromosome contains 240 genes related to diseases, as it is well known as a disease-rich chromosome. Although there are many protein-coding genes, the proteomic identification ratio is rather low. As a model study, human hippocampal tissues from patients suffering from Alzheimer's disease and epilepsy were prepared to evaluate the gene-centric statistics related to the gene expression and disorders of chromosome 11. A total of 8828 protein coding genes from brain tissues were extensively off-gel fractionated and profiled by a high resolution mass spectrometer with collision induced dissociation and electron transfer dissociation. Five-hundred twenty-three of the proteins from brain tissues were determined to belong to chromosome 11, representing 37% of the proteins reported in the Global Proteome Machine Database. We extracted gene clusters from a specific biological process or molecular function in gene ontology, among which the olfactory receptor genes showed the largest cluster on chromosome 11. Analysis of the proteome data set from the hippocampus provides a significant network associated with genes and proteins and leads to new insights into the biological and genetic mechanisms of chromosome 11-specific diseases such as Alzheimer's disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF PROTEOME RESEARCH | - |
dc.subject | GENES | - |
dc.subject | 11P15.5 | - |
dc.subject | PROJECT | - |
dc.subject | SYSTEM | - |
dc.subject | GENOME | - |
dc.title | Chromosome 11-Centric Human Proteome Analysis of Human Brain Hippocampus Tissue | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000313156300024 | - |
dc.identifier.doi | 10.1021/pr3008368 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PROTEOME RESEARCH, v.12, no.1, pp.97 - 105 | - |
dc.identifier.scopusid | 2-s2.0-84874031135 | - |
dc.citation.endPage | 105 | - |
dc.citation.startPage | 97 | - |
dc.citation.title | JOURNAL OF PROTEOME RESEARCH | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Lee, Bonghee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | chromosome 11 | - |
dc.subject.keywordAuthor | chromosomal Human Proteome Project | - |
dc.subject.keywordAuthor | hippocampus | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | epilepsy | - |
dc.subject.keywordAuthor | collision induced dissociation/electron transfer dissociation | - |
dc.subject.keywordAuthor | offgel fractionation | - |
dc.subject.keywordAuthor | olfactory receptor | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | 11P15.5 | - |
dc.subject.keywordPlus | PROJECT | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | GENOME | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.