KIT D816 mutation associates with adverse outcomes in core binding factor acute myeloid leukemia, especially in the subgroup with RUNX1/RUNX1T1 rearrangement
DC Field | Value | Language |
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dc.contributor.author | Kim, Hee-Jin | - |
dc.contributor.author | Ahn, Hee Kyung | - |
dc.contributor.author | Jung, Chul Won | - |
dc.contributor.author | Moon, Joon Ho | - |
dc.contributor.author | Park, Chang-Hun | - |
dc.contributor.author | Lee, Ki-O | - |
dc.contributor.author | Kim, Sun-Hee | - |
dc.contributor.author | Kim, Yeo-Kyeoung | - |
dc.contributor.author | Kim, Hyeoung-Joon | - |
dc.contributor.author | Sohn, Sang Kyun | - |
dc.contributor.author | Kim, Sung Hyun | - |
dc.contributor.author | Lee, Won Sik | - |
dc.contributor.author | Kim, Kyoung Ha | - |
dc.contributor.author | Mun, Yeung-Chul | - |
dc.contributor.author | Kim, Hawk | - |
dc.contributor.author | Park, Jinny | - |
dc.contributor.author | Min, Woo-Sung | - |
dc.contributor.author | Kim, Hee-Je | - |
dc.contributor.author | Kim, Dong Hwan Dennis | - |
dc.date.available | 2020-02-29T00:46:07Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 0939-5555 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14832 | - |
dc.description.abstract | Core binding factor (CBF)-positive acute myeloid leukemia (AML) presents a favorable prognosis, except for patients with KIT mutation, especially D816 mutation. The current retrospective study attempted to validate a prognostic role of KIT mutation in 121 Korean patients with CBF AML. The study patients consisted of 121 patients with CBF AML (82 patients with RUNX1/RUNX1T1 [67.8 %] and 39 patients with CBFB/MYH11 [32.2 %]) recruited from eight institutions in Korea. All patients received idarubicin plus cytarabine or behenoyl cytosine arabinoside 3 + 7 induction chemotherapy. The KIT gene mutation status was determined by direct sequencing analyses. A KIT mutation was detected in 32 cases (26.4 %) in our series of patients. The KIT mutation was most frequent in exon 17 (n = 18, 14.9 %; n = 16 with D816 mutation), followed by exon 8 (n = 10, 8.3 %). The presence of KIT D816 mutation was associated with adverse outcomes for the event-free survival (p = 0.03) and for the overall survival (p = 0.02). The unfavorable impact of D816 mutation was more prominent when the analysis was confined to the RUNX1/RUNX1T1 subtype. The KIT mutation was detected in 26.4 % of Korean patients with CBF AML. The KIT D816 mutation demonstrated an unfavorable prognostic implication, particularly in the RUNX1/RUNX1T1 subtype. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | ANNALS OF HEMATOLOGY | - |
dc.subject | C-KIT | - |
dc.subject | PROGNOSTIC IMPACT | - |
dc.subject | GROUP-B | - |
dc.subject | T(8/21) | - |
dc.subject | GENE | - |
dc.subject | FLT3 | - |
dc.subject | AML | - |
dc.subject | INV(16) | - |
dc.subject | CANCER | - |
dc.subject | FUSION | - |
dc.title | KIT D816 mutation associates with adverse outcomes in core binding factor acute myeloid leukemia, especially in the subgroup with RUNX1/RUNX1T1 rearrangement | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000313445100003 | - |
dc.identifier.doi | 10.1007/s00277-012-1580-5 | - |
dc.identifier.bibliographicCitation | ANNALS OF HEMATOLOGY, v.92, no.2, pp.163 - 171 | - |
dc.identifier.scopusid | 2-s2.0-84872345873 | - |
dc.citation.endPage | 171 | - |
dc.citation.startPage | 163 | - |
dc.citation.title | ANNALS OF HEMATOLOGY | - |
dc.citation.volume | 92 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Ahn, Hee Kyung | - |
dc.contributor.affiliatedAuthor | Park, Jinny | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Core binding factor-positive acute myeloid leukemia | - |
dc.subject.keywordAuthor | KIT | - |
dc.subject.keywordAuthor | Mutation | - |
dc.subject.keywordAuthor | Korea | - |
dc.subject.keywordPlus | C-KIT | - |
dc.subject.keywordPlus | PROGNOSTIC IMPACT | - |
dc.subject.keywordPlus | GROUP-B | - |
dc.subject.keywordPlus | T(8/21) | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | FLT3 | - |
dc.subject.keywordPlus | AML | - |
dc.subject.keywordPlus | INV(16) | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | FUSION | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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